2. Cell Cycle/DNA Damage
  3. CDK
  4. Palbociclib-d8

Palbociclib-d8  (Synonyms: PD 0332991-d8)

Cat. No.: HY-50767S Purity: 99.84%
COA Handling Instructions

Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

For research use only. We do not sell to patients.

Palbociclib-d<sub>8</sub> Chemical Structure

Palbociclib-d8 Chemical Structure

CAS No. : 1628752-83-9

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1 mg USD 320 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Palbociclib-d8:

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Description

Palbociclib-d8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

IC50 & Target[1]

Cdk4/cyclin D3

9 nM (IC50)

Cdk4/cyclin D1

11 nM (IC50)

Cdk6/cyclin D2

16 nM (IC50)

DYRK1A

2000 nM (IC50)

MAPK

8000 nM (IC50)

Molecular Weight

455.58

Appearance

Solid

Formula

C24H21D8N7O2
CAS No.
SMILES

O=C1N(C2=NC(NC3=NC=C(C=C3)N4C([2H])(C([2H])(NC([2H])(C4([2H])[2H])[2H])[2H])[2H])=NC=C2C(C)=C1C(C)=O)C5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 8.33 mg/mL (18.28 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)

DMSO : 1 mg/mL (2.20 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1950 mL 10.9750 mL 21.9500 mL
5 mM 0.4390 mL 2.1950 mL 4.3900 mL
10 mM 0.2195 mL 1.0975 mL 2.1950 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.84%

COA (251 KB) HNMR (212 KB) RP-HPLC (367 KB) MS (151 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Palbociclib-d81628752-83-9PD 0332991-d8CDKCyclin dependent kinaseDeuteriumlabeledCDK4CDK6anticancerInhibitorinhibitorinhibit

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