1. Cell Cycle/DNA Damage
  2. CDK
  3. Palbociclib D8

Palbociclib D8 (Synonyms: PD 0332991 D8)

Cat. No.: HY-50767S
Handling Instructions

Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities.

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Palbociclib D8 Chemical Structure

Palbociclib D8 Chemical Structure

CAS No. : 1628752-83-9

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Description

Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has no activity against other protein kinases. Palbociclib has potently anticancer activities[1].

IC50 & Target[1]

Cdk4/cyclin D3

9 nM (IC50)

Cdk4/cyclin D1

11 nM (IC50)

Cdk6/cyclin D2

16 nM (IC50)

DYRK1A

2000 nM (IC50)

MAPK

8000 nM (IC50)

Molecular Weight

455.58

Formula

C₂₄H₂₁D₈N₇O₂

CAS No.

1628752-83-9

SMILES

O=C1N(C2=NC(NC3=NC=C(C=C3)N4C([2H])(C([2H])(NC([2H])(C4([2H])[2H])[2H])[2H])[2H])=NC=C2C(C)=C1C(C)=O)C5CCCC5

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Keywords:

Palbociclib D8PD 0332991 D8Palbociclib D 8Palbociclib D-8CDKCyclin dependent kinaseDeuteriumlabeledCDK4CDK6anticancerInhibitorinhibitorinhibit

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