PROTAC CDK6 Degrader 2
PROTAC CDK6 Degrader 2 (compound 48b), the active form of PROTAC CDK6 Degrader 1 (HY-180277), is a potent and selective PROTAC CDK6 degrader that binds strongly to KLHDC2 (KD = 0.005 μM). PROTAC CDK6 Degrader 2 functions through a KLHDC2-dependent and ubiquitin-proteasome-mediated mechanism. PROTAC CDK6 Degrader 2 can be used for cancer research.
(Pink: CDK6 ligand (HY-180278); Blue: KLHDC2 ligand (HY-180263); Black: linker).
For research use only. We do not sell to patients.
- Formula: C69H87N15O8
- Molecular Weight:1254.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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CDK6 |
Chemical Information
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Molecular Weight 1254.52
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Formula C69H87N15O8
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SMILES
O=C([C@@H]1CN(CCC1)C2=C3C=CC=CC3=CN=C2)N(CC4=CN(N=C4)CC(O)=O)CCNC([C@H]5CC[C@H](C(N6CCC7(CC(C7)N8CCC(CC8)C(N9CCN(C%10=CN=C(NC%11=NC=C%12C(N(C(C(C(C)=O)=C%12C)=O)C%13CCCC%13)=N%11)C=C%10)CC9)=O)CC6)=O)CC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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