HMGA1 - high mobility group AT-hook 1 Gene

Also Known as HMG-R; HMGIY; HMGA1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3159

About HMGA1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,236,873-34,246,231 (from NCBI)

This gene has 9 transcripts (splice variants), 103 orthologues and is associated with 33 phenotypes. Broad expression in lymph node (RPKM 58.3), bone marrow (RPKM 57.3) and 23 other tissues.

Summary

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of Cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

HMGA1 Products (12)

mRNA	Protein	Name
NM_001319077.2	NP_001306006.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001319078.2	NP_001306007.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319079.2	NP_001306008.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319080.2	NP_001306009.1	high mobility group protein HMG-I/HMG-Y isoform c
NM_001319081.2	NP_001306010.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319082.2	NP_001306011.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_002131.4	NP_002122.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145899.3	NP_665906.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_145901.3	NP_665908.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_145902.3	NP_665909.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145903.3	NP_665910.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145905.3	NP_665912.1	high mobility group protein HMG-I/HMG-Y isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: Inferred from direct assay	19465398	GOA
enables DNA binding	EXP EXP: Inferred from Experiment	9253416	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	11069991	GOA
enables DNA binding, bending	EXP EXP: Inferred from Experiment	22615915	GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	19465398	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	21087998	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9253416	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16157300	GOA
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	9253416	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11069991	GOA
enables molecular function activator activity	IMP IMP: Inferred from mutant phenotype	21087998	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	10428834	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: Inferred from direct assay	10428834	GOA
enables nuclear retinoid X receptor binding	IDA IDA: Inferred from direct assay	10428834	GOA
enables peroxisome proliferator activated receptor binding	IDA IDA: Inferred from direct assay	10428834	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9809067	GOA
enables transcription coactivator activity	EXP EXP: Inferred from Experiment	9253416	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	10428834	GOA
enables transcription coregulator binding	IDA IDA: Inferred from direct assay	10428834	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in base-excision repair	IDA IDA: Inferred from direct assay	19465398	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16901784	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16901784	GOA
involved in oncogene-induced cell senescence	IDA IDA: Inferred from direct assay	16901784	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10428834	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	16901784	GOA
located in senescence-associated heterochromatin focus	IDA IDA: Inferred from direct assay	16901784	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGA1 Protein Structure

AT_hook

0
100
107 a.a.

Protein Preferred Names	Protein Names
high mobility group protein HMG-I/HMG-Y	high mobility group protein A1

HMGA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HMGA1	P17096	H1-3	Homo sapiens	P16402	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2BC21	Homo sapiens	Q16778	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	33961781
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Crosslink	30021884
Intra	HMGA1	P17096	H4C16	Homo sapiens	P62805	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	Pull Down	18234858
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	Anti Bait CoIP	18234858
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	BiFC	18234858

Cross: Cross-species interaction Intra: Intraspecies interaction

HMGA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81440	HMGA1 Antibody (YA1185)	IHC-P	Human
HY-P81440A	HMGA1 Antibody (YA1185)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Pelvic Lipomatosis	Excess Of Mature Unencapsulated Fatty Tissue In The Pelvis
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Leiomyoma, Uterine	Uterine Leiomyoma Uterine Fibroid Uterine Fibroids Plexiform Leiomyoma UL Leiomyoma Of Corpus Uteri Uterus Fibroma
Breast Fibroadenoma	Fibroadenoma Fibroadenoma Of Breast Juvenile Fibroadenoma Of Breast Cellular Fibroadenoma Complex Fibroadenoma Of Breast Juvenile Fibroadenoma Fibroadenoma Nos Fibroadenoma Unspecified Site
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06230	HMGA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17912	Hmga1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-184535	PDIC-DPC		/	Unkown
HY-RS24381	Hmga1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HMGA1	RGD	RGD:628699
Bos taurus	HMGA1	VGNC	VGNC:29874
Mus musculus	HMGA1	MGD	MGI:96160
Canis familiaris	HMGA1	VGNC	VGNC:41709
Macaca mulatta	HMGA1	VGNC	VGNC:81076
Others	HMGA1	NCBI