Netropsin

Cat. No.: HY-N6800: Data Sheet Handling Instructions
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Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder) and antibiotic, inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin dihydrochloride has antibacterial and antiviral activity.

For research use only. We do not sell to patients.

Netropsin Chemical Structure

CAS No. : 1438-30-8

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Netropsin:

Netropsin dihydrochloride

Other Forms of Netropsin:

Netropsin dihydrochloride In-stock

1 Publications Citing Use of MCE Netropsin

•PLoS Pathog. 2026 Jan 26;22(1):e1013903. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
DC3F	IC₅₀	3.2 mM Compound: Netropsin	Cytotoxicity against hamster DC-3F cells Cytotoxicity against hamster DC-3F cells	[PMID: 20471276]
HT-29	IC₅₀	44.7 μM Compound: Netropsin	Inhibitory concentration that reduced the viability of HT 29 cell population by 50%. Inhibitory concentration that reduced the viability of HT 29 cell population by 50%.	[PMID: 9003520]
K562	IC₅₀	> 50 μM Compound: Netropsin	Cytotoxicity against human K562 cells after 72 hrs by MTS assay Cytotoxicity against human K562 cells after 72 hrs by MTS assay	[PMID: 20471276]
KB	IC₅₀	47.1 μM Compound: Netropsin	Inhibitory concentration that reduced the viability of KB cell population by 50%. Inhibitory concentration that reduced the viability of KB cell population by 50%.	[PMID: 9003520]
SK-VLB	IC₅₀	> 10 μM Compound: Netropsin	Inhibitory concentration that reduced the viability of SKVLB cell population by 50%. Inhibitory concentration that reduced the viability of SKVLB cell population by 50%.	[PMID: 9003520]

Molecular Weight

430.46

Formula

C₁₈H₂₆N₁₀O₃

CAS No.

1438-30-8

SMILES

O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2

Structure Classification

Others

Initial Source

Microorganisms

Streptomyces netropsis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beerman TA et al. Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta. 1991 Aug 27;1090(1):52-60. [Content Brief]

[2]. Finlay A C, et al. Netropsin, a new antibiotic produced by a Streptomyces. Journal of the American Chemical Society, 1951, 73(1): 341-343.

Netropsin Related Classifications

Inflammation/Immunology Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Netropsin1438-30-8AntibioticDNA/RNA SynthesisBacterialInfluenza VirusOrthopoxvirusInhibitorinhibitorinhibit

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