H1-3 - H1.3 linker histone, cluster member Gene

Also Known as H1D; H1.3; H1F3; H1s-2; HIST1H1D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3007

About H1-3

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,234,212-26,234,987 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-3 Products (1)

mRNA Protein Name
NM_005320.3 NP_005311.1 histone H1.3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
15911621 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
19882353 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
15911621 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-3 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (39 - 110)

  • 0
  • 100
  • 200
  • 221 a.a.
Protein Preferred Names Protein Names

histone H1.3

  • H1 histone family, member 3

H1-3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H1-3 P16402 HMGA1 Homo sapiens P17096
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

H1-3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83304 Phospho-Histone H1.4 (Thr17) Antibody (YA3049) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Ophthalmomyiasis

  • Ocular Myiasis

  • Ophthalmic Myiasis

  • Myiasis Oestruosa
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19120 KB-5492 anhydrous Inhibitor 99.50% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-41404 Piperonylic acid Inhibitor 99.94% Unkown
HY-B1047 Carsalam 99.91% Unkown
HY-47228 KB-5492 free base Inhibitor 99.02% Unkown
HY-137566 Cucumarioside H / Unkown
HY-162602 EGFR-IN-115 Inhibitor / Unkown
HY-RS05948 H1-3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06222 HM13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W086270 2-(4-Nitrophenyl)-1H-1,3-benzodiazole-6-carboxylic acid / Unkown
HY-W243980 2-(1H-Benzo[d]imidazol-1-yl)benzoic acid / Unkown
HY-170685 1-(2H-1,3-benzodioxol-5-yl)-2-[(propan-2-yl)amino]propan-1-one hydrochloride / Unkown
HY-170768 Alkaline tryptase-IN-1 Inhibitor / Unkown
HY-W811579 Bensuldazic acid Inhibitor / Unkown
HY-W811579A Bensuldazic acid sodium Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta H1-3 VGNC VGNC:109745
Mus musculus H1-3 MGD MGI:107502
Felis catus H1-3 VGNC VGNC:109856
Rattus norvegicus H1-3 RGD RGD:1585568
Others H1-3 NCBI