1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. KB-5492 anhydrous

KB-5492 anhydrous 

Cat. No.: HY-19120 Purity: 99.50%
Handling Instructions

KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent.

For research use only. We do not sell to patients.

KB-5492 anhydrous Chemical Structure

KB-5492 anhydrous Chemical Structure

CAS No. : 129200-10-8

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5 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent[1][2].

IC50 & Target

IC50: 3.15 μM (sigma receptor)[1]

In Vitro

KB-5492 (0.001-100 μM) inhibits specific [3H]DTG binding in a concentration-dependent manner[1].
KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2].

In Vivo

KB-5492 (200 mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa[2].

Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage[2]
Dosage: 200 mg/kg
Administration: Oral gavage
Result: Reduced the lesion length as compared with the control.
Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
Molecular Weight

546.57

Formula

C₂₇H₃₄N₂O₁₀

CAS No.

129200-10-8

SMILES

O=C(OC1=CC=C(OC)C=C1)CN2CCN(CC3=CC(OC)=C(OC)C(OC)=C3)CC2.O=C(O)/C=C/C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (457.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8296 mL 9.1480 mL 18.2959 mL
5 mM 0.3659 mL 1.8296 mL 3.6592 mL
10 mM 0.1830 mL 0.9148 mL 1.8296 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

  • 6.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.50%

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Keywords:

KB-5492KB5492KB 5492Sigma ReceptorSigmaDTGanti-ulcerInhibitorinhibitorinhibit

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Product Name:
KB-5492 anhydrous
Cat. No.:
HY-19120
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