2. Neuronal Signaling
  3. Sigma Receptor
  4. KB-5492 free base

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent.

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KB-5492 free base Chemical Structure

KB-5492 free base Chemical Structure

CAS No. : 113594-64-2

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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KB-5492 free base Related Antibodies

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Description

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2].

IC50 & Target

IC50: 3.15 μM (sigma receptor)[1]
In Vitro

KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner[1].
KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KB-5492 free base Related Antibodies
In Vivo

KB-5492 (200 mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage[2]
Dosage: 200 mg/kg
Administration: Oral gavage
Result: Reduced the lesion length as compared with the control.
Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.
Molecular Weight

430.49

Formula

C23H30N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1=CC=C(OC)C=C1)CN2CCN(CC3=CC(OC)=C(OC)C(OC)=C3)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (232.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3229 mL 11.6147 mL 23.2293 mL
5 mM 0.4646 mL 2.3229 mL 4.6459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3229 mL 11.6147 mL 23.2293 mL 58.0734 mL
5 mM 0.4646 mL 2.3229 mL 4.6459 mL 11.6147 mL
10 mM 0.2323 mL 1.1615 mL 2.3229 mL 5.8073 mL
15 mM 0.1549 mL 0.7743 mL 1.5486 mL 3.8716 mL
20 mM 0.1161 mL 0.5807 mL 1.1615 mL 2.9037 mL
25 mM 0.0929 mL 0.4646 mL 0.9292 mL 2.3229 mL
30 mM 0.0774 mL 0.3872 mL 0.7743 mL 1.9358 mL
40 mM 0.0581 mL 0.2904 mL 0.5807 mL 1.4518 mL
50 mM 0.0465 mL 0.2323 mL 0.4646 mL 1.1615 mL
60 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.9679 mL
80 mM 0.0290 mL 0.1452 mL 0.2904 mL 0.7259 mL
100 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.5807 mL
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KB-5492 free base Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KB-5492113594-64-2KB5492KB 5492Sigma ReceptorSigmaDTGanti-ulcerInhibitorinhibitorinhibit

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