113594-64-2
113594-64-2
Chemical Structure
KB-5492 free base
- CAS No.: 113594-64-2
- Formula:C23H30N2O6
- Molecular Weight:430.49
IUPAC Name: 4-methoxyphenyl 2-(4-(3,4,5-trimethoxybenzyl)piperazin-1-yl)acetate
InChIKey: RVYZAZTXLLAVGZ-UHFFFAOYSA-N
SMILES: O=C(OC1=CC=C(OC)C=C1)CN2CCN(CC3=CC(OC)=C(OC)C(OC)=C3)CC2
Biological Activity: KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent[1][2].
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KB-5492 free base | 99.02% | KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent. | ||||||||||||||||||||
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References
- [1]. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8. [Content Brief]
- [2]. Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64(1): 41-7. [Content Brief]
Keywords
