HMGA1 Antibody (YA1185)(PBS only)
(Synonyms: HMG R; HMG-I(Y); HMGA1; HMGA1A; HMGIY)HMGA1 Antibody (YA1185) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGA1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
HMGA1 Antibody (YA1185) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HMGA1.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 17 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 12 kDa
A synthesized peptide derived from human HMGA1
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HMGA1 is a HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions
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Subcellular Localization
Nucleus; Chromosome
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Isoforms & Post-Translational Modification
P17096 has 3 isomers: P17096-1: 11676 Da (predicted); P17096-2: 10679 Da (predicted); P17096-3: 19694 Da (predicted).
Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity;HMG-Y is not methylated;Methylation at Arg-58 is mutually exclusive with methylation at Arg-60 -
Subunit
Interacts with HIPK2 (By similarity)
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SwissProt ID
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Synonyms
HMG R; HMG-I(Y); HMGA1; HMGA1A; HMGIY
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Research Field
Microbiology
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