FDX2 - ferredoxin 2 Gene

Also Known as FDX1L; MEOAL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112812

About FDX2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,310,045-10,316,015 (from NCBI)

This gene has 7 transcripts (splice variants), 180 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]

FDX2 Products (1)

mRNA	Protein	Name
NM_001397406.1	NP_001384335.1	ferredoxin-2, mitochondrial

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables electron transfer activity	IDA IDA: Inferred from direct assay	28001042	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in [2Fe-2S] cluster assembly	IDA IDA: Inferred from direct assay	28001042	GOA
acts upstream of [4Fe-4S] cluster assembly	IDA IDA: Inferred from direct assay	28001042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FDX2 Protein Structure

Fer2

0
100
183 a.a.

Protein Preferred Names	Protein Names
ferredoxin-2, mitochondrial	adrenodoxin-like protein, mitochondrial

FDX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FDX2	Q6P4F2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	FDX2	Q6P4F2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	FDX2	Q6P4F2	LHX4	Homo sapiens	Q969G2	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

FDX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89907	FDX1L Antibody (YA9251)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Mitochondrial Myopathy, Episodic, With Or Without Optic Atrophy And Reversible Leukoencephalopathy	Mitochondrial Myopathy, Episodic, With Optic Atrophy And Reversible Leukoencephalopathy MEOAL Mitochondrial Myopathy, Episodic, Without Optic Atrophy And Reversible Leukoencephalopathy
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Combined Oxidative Phosphorylation Deficiency 19	COXPD19 Severe Neonatal Lactic Acidosis Due To Nfs1-Isd11 Complex Deficiency Combined Oxidative Phosphorylation Deficiency, Type 19
Myopathy	Muscular Diseases Myopathies
Nephrotic Syndrome, Type 9	NPHS9 Nephrotic Syndrome Type 9 Nephrotic Syndrome 9
Multiple Mitochondrial Dysfunctions Syndrome 1	MMDS1 Mmds Nfu1 Deficiency Multiple Mitochondrial Dysfunctions Syndrome Type 1 Mitochondrial Dysfunctions Syndrome, Multiple, Type 1
Multiple Mitochondrial Dysfunctions Syndrome	Fatal Multiple Mitochondrial Dysfunctions Syndrome Fatal Multiple Mitochondrial Dysfunction Syndrome Mmds Multiple Mitochondrial Dysfunction Syndrome Mitochondrial Dysfunctions, Multiple, Syndrome Multiple Mitochondrial Dysfunctions Syndrome 1
Multiple Mitochondrial Dysfunctions Syndrome 3	MMDS3 Iba57 Deficiency Multiple Mitochondrial Dysfunctions Syndrome Type 3 Mitochondrial Dysfunctions, Multiple, Syndrome, Type 3
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia	Multiple Mitochondrial Dysfunctions Syndrome 2 MMDS2 Bola3 Deficiency Multiple Mitochondrial Dysfunctions Syndrome Type 2 Mitochondrial Dysfunctions Syndrome, Multiple, Type 2
Cataract 34, Multiple Types	Cataract, Autosomal Recessive Congenital 3 Cataract 34 Multiple Types CTRCT34 Catc3 Cataract 34, Multiple Types, With Or Without Microcornea Autosomal Recessive Congenital Cataract 3 Cataract 34 Multiple Types With Or Without Microcornea Cataract, Multiple Types, Type 34
Glycine Encephalopathy	Non-Ketotic Hyperglycinemia Nonketotic Hyperglycinemia NKH GCE Hyperglycinemia, Nonketotic Hyperglycinemia Nonketotic Infantile Glycine Encephalopathy Encephalopathy, Glycine Glycine Synthase Deficiency Nka Neonatal Glycine Encephalopathy Classic Glycine Encephalopathy Neonatal Nkh Neonatal Non-Ketotic Hyperglycinemia Infantile Nkh Infantile Non-Ketotic Hyperglycinemia Non-Ketotic Hyperglycinaemia Glycine Cleavage Deficiency Nonketotic Hyperglycinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04855	FDX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FDX2	RGD	RGD:1561264
Bos taurus	FDX2	VGNC	VGNC:55209
Mus musculus	FDX2	MGD	MGI:1915415
Felis catus	FDX2	VGNC	VGNC:102583
Others	FDX2	NCBI