FDX2 - ferredoxin 2 Gene

Homo sapiens

Also known as FDX1L; MEOAL

Gene ID: 112812 | Gene type: protein coding

About FDX2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,310,045-10,316,015 (from NCBI)

This gene has 7 transcripts (splice variants), 180 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.3) and 25 other tissues.

Summary

This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]

FDX2 Products(1)

mRNA	Protein	Name
NM_001397406.1	NP_001384335.1	ferredoxin-2, mitochondrial

FDX2 Protein Structure

Fer2

0
100
183 a.a.

Protein Preferred Names

Protein Names

ferredoxin-2, mitochondrial

adrenodoxin-like protein, mitochondrial

Related Diseases

Diseases

Alias

Mitochondrial Myopathy, Episodic, With Or Without Optic Atrophy And Reversible Leukoencephalopathy

Mitochondrial Myopathy, Episodic, With Optic Atrophy And Reversible Leukoencephalopathy	MEOAL
Mitochondrial Myopathy, Episodic, Without Optic Atrophy And Reversible Leukoencephalopathy

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Combined Oxidative Phosphorylation Deficiency 19

COXPD19	Severe Neonatal Lactic Acidosis Due To Nfs1-Isd11 Complex Deficiency
Combined Oxidative Phosphorylation Deficiency, Type 19

Myopathy

Muscular Diseases

Myopathies

Nephrotic Syndrome, Type 9

NPHS9	Nephrotic Syndrome Type 9
Nephrotic Syndrome 9

Multiple Mitochondrial Dysfunctions Syndrome 1

MMDS1	Mmds
Nfu1 Deficiency	Multiple Mitochondrial Dysfunctions Syndrome Type 1
Mitochondrial Dysfunctions Syndrome, Multiple, Type 1

Multiple Mitochondrial Dysfunctions Syndrome

Fatal Multiple Mitochondrial Dysfunctions Syndrome	Fatal Multiple Mitochondrial Dysfunction Syndrome
Mmds	Multiple Mitochondrial Dysfunction Syndrome
Mitochondrial Dysfunctions, Multiple, Syndrome	Multiple Mitochondrial Dysfunctions Syndrome 1

Multiple Mitochondrial Dysfunctions Syndrome 3

MMDS3	Iba57 Deficiency
Multiple Mitochondrial Dysfunctions Syndrome Type 3	Mitochondrial Dysfunctions, Multiple, Syndrome, Type 3

Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia

Multiple Mitochondrial Dysfunctions Syndrome 2	MMDS2
Bola3 Deficiency	Multiple Mitochondrial Dysfunctions Syndrome Type 2
Mitochondrial Dysfunctions Syndrome, Multiple, Type 2

Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3	Cataract 34 Multiple Types
CTRCT34	Catc3
Cataract 34, Multiple Types, With Or Without Microcornea	Autosomal Recessive Congenital Cataract 3
Cataract 34 Multiple Types With Or Without Microcornea	Cataract, Multiple Types, Type 34

Glycine Encephalopathy

Non-Ketotic Hyperglycinemia	Nonketotic Hyperglycinemia
NKH	GCE
Hyperglycinemia, Nonketotic	Hyperglycinemia Nonketotic
Infantile Glycine Encephalopathy	Encephalopathy, Glycine
Glycine Synthase Deficiency	Nka
Neonatal Glycine Encephalopathy	Classic Glycine Encephalopathy
Neonatal Nkh	Neonatal Non-Ketotic Hyperglycinemia
Infantile Nkh	Infantile Non-Ketotic Hyperglycinemia
Non-Ketotic Hyperglycinaemia	Glycine Cleavage Deficiency
Nonketotic Hyperglycinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04855	FDX2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FDX2	RGD	RGD:1561264
Bos taurus	FDX2	VGNC	VGNC:55209
Mus musculus	FDX2	MGD	MGI:1915415
Felis catus	FDX2	VGNC	VGNC:102583