USP25 - ubiquitin specific peptidase 25 Gene

Homo sapiens

Also known as USP21

Gene ID: 29761 | Gene type: protein coding

About USP25

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:15,729,982-15,880,064 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 20.1), endometrium (RPKM 11.0) and 25 other tissues.

Summary

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

USP25 Products(9)

mRNA	Protein	Name
NM_001283041.3	NP_001269970.1	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25m
NM_001283042.3	NP_001269971.1	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25b
NM_001352560.2	NP_001339489.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 4
NM_001352561.2	NP_001339490.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388299.1	NP_001375228.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 4
NM_001388300.1	NP_001375229.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388301.1	NP_001375230.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 5
NM_001388302.1	NP_001375231.1	ubiquitin carboxyl-terminal hydrolase 25 isoform 6
NM_013396.6	NP_037528.3	ubiquitin carboxyl-terminal hydrolase 25 isoform USP25a

USP25 Protein Structure

UIM

UCH

0
200
400
600
800
1000
1055 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 25

USP on chromosome 21

Related Diseases

Diseases

Alias

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

Arthrogryposis, Renal Dysfunction, And Cholestasis 2

ARCS2	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 2
Arthrogryposis Renal Dysfunction And Cholestasis 2

Enterokinase Deficiency

Enteropeptidase Deficiency	Congenital Enterokinase Deficiency
Congenital Enteropathy Due To Enteropeptidase Deficiency	Deficiency Of Enteropeptidase
ENTKD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117370	USP25/28 inhibitor AZ1	Inhibitor	≥98.0%	Unkown
HY-153996	CT1113	Inhibitor	/	Unkown
HY-RS15535	USP25 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP25	RGD	RGD:1309003
Felis catus	USP25	VGNC	VGNC:66875
Mus musculus	USP25	MGD	MGI:1353655
Canis familiaris	USP25	VGNC	VGNC:48184
Bos taurus	USP25	VGNC	VGNC:36718
Macaca mulatta	USP25	VGNC	VGNC:78744
Others	USP25	NCBI

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