NUMA1 - nuclear mitotic apparatus protein 1 Gene

Also Known as NUMA; NMP-22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4926

About NUMA1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,002,864-72,080,542 (from NCBI)

This gene has 33 transcripts (splice variants), 148 orthologues, 3 paralogues and is associated with 88 phenotypes. Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues.

Summary

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

NUMA1 Products (2)

mRNA	Protein	Name
NM_001286561.2	NP_001273490.1	nuclear mitotic apparatus protein 1 isoform 2
NM_006185.4	NP_006176.2	nuclear mitotic apparatus protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables disordered domain specific binding	IMP IMP: Inferred from mutant phenotype	20109190	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	10811826	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	11956313	GOA
enables microtubule minus-end binding	IDA IDA: Inferred from direct assay	26765568	GOA
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	26765568	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	24371089	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11590136	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22074847	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11590136	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	11956313	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in anastral spindle assembly	IMP IMP: Inferred from mutant phenotype	25657325	GOA
involved in astral microtubule organization	IDA IDA: Inferred from direct assay	12445386	GOA
involved in astral microtubule organization	IMP IMP: Inferred from mutant phenotype	12445386	GOA
involved in establishment of mitotic spindle orientation	IDA IDA: Inferred from direct assay	21816348	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	24996901	GOA
involved in microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	12445386	GOA
involved in positive regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	24371089	GOA
involved in positive regulation of chromosome separation	IMP IMP: Inferred from mutant phenotype	23921553	GOA
involved in positive regulation of intracellular transport	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	12445386	GOA
involved in positive regulation of mitotic spindle elongation	IMP IMP: Inferred from mutant phenotype	23921553	GOA
involved in positive regulation of protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	22327364	GOA
involved in positive regulation of protein localization to spindle pole body	IDA IDA: Inferred from direct assay	16076287	GOA
involved in positive regulation of spindle assembly	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in regulation of metaphase plate congression	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in regulation of mitotic spindle organization	IDA IDA: Inferred from direct assay	26195665	GOA
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	11956313	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell cortex	IDA IDA: Inferred from direct assay	22327364	GOA
located in cell cortex region	IDA IDA: Inferred from direct assay	21816348	GOA
located in centrosome	IDA IDA: Inferred from direct assay	7962183	GOA
located in cortical microtubule	IDA IDA: Inferred from direct assay	26765568	GOA
located in cytoplasmic microtubule bundle	IDA IDA: Inferred from direct assay	12445386	GOA
located in cytosol	IDA IDA: Inferred from direct assay	7962183	GOA
located in microtubule bundle	IDA IDA: Inferred from direct assay	11956313	GOA
located in microtubule minus-end	IDA IDA: Inferred from direct assay	26765568	GOA
located in microtubule plus-end	IDA IDA: Inferred from direct assay	26765568	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	10811826	GOA
located in mitotic spindle astral microtubule	IDA IDA: Inferred from direct assay	1541636	GOA
located in mitotic spindle midzone	IDA IDA: Inferred from direct assay	10811826	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	1541636	GOA
located in mitotic spindle pole	IMP IMP: Inferred from mutant phenotype	17172455	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	7962183	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	10811826	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1541636	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24371089	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22074847	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	20109190	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	1541636	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	14718566	GOA
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	10811826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nuclear mitotic apparatus protein 1	SP-H antigen

NUMA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUMA1	Q14980	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	NUMA1	Q14980	KRT4	Homo sapiens	P19013	Crosslink	30021884
Intra	NUMA1	Q14980	GNAI1	Homo sapiens	P63096	Pull Down	15537540
Intra	NUMA1	Q14980	GPSM2	Homo sapiens	P81274	Pull Down	15537540
Intra	NUMA1	Q14980	GPSM2	Homo sapiens	P81274	IF	15537540
Intra	NUMA1	Q14980	RAE1	Homo sapiens	P78406	Anti Tag CoIP	35271311
Intra	NUMA1	Q14980	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

NUMA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81781	Nuclear Mitotic Apparatus Protein 1 Antibody (YA1526)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P86658	Nuclear Mitotic Apparatus Protein 1 Antibody (YA6350)	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, ELISA, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Bladder Calculus	Urinary Bladder Calculi Urinary Bladder Stone Bladder Calculi Bladder Stone Urinary Bladder Calculus Vesical Calculi Vesical Calculus Vesicolithiasis Cystolithiasis Cystic Calculi Cystic Calculus
Lower Urinary Tract Calculus	Calculus Of Lower Urinary Tract
Ureter Adenocarcinoma	Adenocarcinoma Of Ureter Ureteral Adenocarcinoma
Non-Invasive Bladder Papillary Urothelial Neoplasm	Bladder Papillary Neoplasm Of Low Malignant Potential Bladder Punlmp Papillary Urothelial Neoplasm Of Low Malignant Potential Papillary Transitional Cell Neoplasm Of Low Malignant Potential
Cherubism	CRBM Familial Benign Giant-Cell Tumor Of The Jaw Familial Fibrous Dysplasia Of Jaw Familial Multilocular Cystic Disease Of The Jaws
Ureter, Cancer Of	Ureter Carcinoma Ureter Cancer Ureteral Neoplasms Malignant Neoplasm Of Ureter Malignant Tumour Of Ureter Malignant Ureteral Tumor Ureteral Carcinoma Ureteral Neoplasm
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Bladder Papillary Transitional Cell Neoplasm	Urinary Bladder Papillary Urothelial Neoplasm Bladder Papillary Urothelial Neoplasm
Urinary Tract Papillary Transitional Cell Benign Neoplasm	Inverted Papilloma Of Urinary Tract Papillary Transitional Cell Neoplasm Of The Urinary Tract Urinary Tract Inverted Papilloma Inverted Urothelial Papilloma
Bladder Carcinoma In Situ	Carcinoma In Situ Of Bladder Bladder Ca In Situ Flat Cis Of The Urinary Bladder Carcinoma In Situ Of Urinary Bladder
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Pyuria	Pus Cells In Urine
Invasive Bladder Transitional Cell Carcinoma	Invasive Bladder Urothelial Carcinoma Infiltrating Bladder Urothelial Carcinoma
Chronic Cystitis
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09680	NUMA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21675	Numa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28193	Numa1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUMA1	VGNC	VGNC:32348
Rattus norvegicus	NUMA1	RGD	RGD:1308777
Macaca mulatta	NUMA1	VGNC	VGNC:75556
Felis catus	NUMA1	VGNC	VGNC:68594
Canis familiaris	NUMA1	VGNC	VGNC:44042
Mus musculus	NUMA1	MGD	MGI:2443665
Others	NUMA1	NCBI