KRT4 - keratin 4 Gene

Also Known as K4; CK4; CK-4; CYK4; WSN1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3851

About KRT4

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,806,549-52,814,116 (from NCBI)

This gene has 5 transcripts (splice variants), 96 orthologues, 68 paralogues and is associated with 3 phenotypes. Restricted expression toward esophagus (RPKM 10134.3).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT4 Products (1)

mRNA	Protein	Name
NM_002272.4	NP_002263.3	keratin, type II cytoskeletal 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17709412	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21371075	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	17709412	GOA
located in intermediate filament cytoskeleton	IDA IDA: Inferred from direct assay	21371075	GOA
located in keratin filament	IDA IDA: Inferred from direct assay	21371075	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT4 Protein Structure

Filament

0
100
200
300
400
500
594 a.a.

Protein Preferred Names	Protein Names
keratin, type II cytoskeletal 4	cytokeratin 4

KRT4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT4	P19013	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	KRT4	P19013	KRT13	Homo sapiens	A1A4E9	Y2H Array	25416956
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Y2H Array	31515488
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	KRT4	P19013	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	KRT4	P19013	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT4	P19013	KRT38	Homo sapiens	O76015	Y2H Array	31515488
Intra	KRT4	P19013	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	KRT4	P19013	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	KRT4	P19013	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT4	P19013	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	KRT4	P19013	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT4	P19013	KRT33B	Homo sapiens	Q14525	Y2H Array	25416956
Intra	KRT4	P19013	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT4	P19013	KRT33B	Homo sapiens	Q14525	Y2H Array	31515488
Intra	KRT4	P19013	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	25416956
Intra	KRT4	P19013	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT4	P19013	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT4	P19013	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	KRT4	P19013	TUBGCP4	Homo sapiens	Q9UGJ1-2	Validated Y2H	32296183
Intra	KRT4	P19013	TUBGCP4	Homo sapiens	Q9UGJ1-2	Y2H Array	32296183
Intra	KRT4	P19013	TUBGCP4	Homo sapiens	Q9UGJ1-2	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	KRT4	P19013	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	KRT4	P19013	CEP57	Homo sapiens	Q86XR8-3	Validated Y2H	32296183
Intra	KRT4	P19013	CEP57	Homo sapiens	Q86XR8-3	Y2H Array	32296183
Intra	KRT4	P19013	CEP57	Homo sapiens	Q86XR8-3	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT4	P19013	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT4	P19013	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT4	P19013	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT4	P19013	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	KRT4	P19013	KRT13	Homo sapiens	P13646	Y2H Array	31515488
Intra	KRT4	P19013	KRT13	Homo sapiens	P13646	Y2H Array	32296183
Intra	KRT4	P19013	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	KRT4	P19013	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KRT4	P19013	KRT24	Homo sapiens	Q2M2I5	Validated Y2H	32296183
Intra	KRT4	P19013	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	KRT4	P19013	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT4	P19013	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT4	P19013	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT4	P19013	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	NUMA1	Homo sapiens	Q14980	Anti Tag CoIP	33961781
Intra	KRT4	P19013	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	KRT4	P19013	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT4	P19013	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	KRT4	P19013	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT4	P19013	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT4	P19013	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT4	P19013	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	KRT4	P19013	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Cross	KRT4	P19013	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82017	Cytokeratin 4 Antibody (YA1762)	WB, IP	Human, Rat
HY-P82017A	Cytokeratin 4 Antibody (YA1762)(PBS only)	WB, IP	Human, Rat
HY-P85906	Cytokeratin 4 Antibody (YA5598)	IHC-P, WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Leukoplakia	Leukoplakia Of Gingiva Leukoplakia Of Oral Epithelium Leucoplakia Of Oral Mucosa Leukokeratosis Of Oral Mucosa
Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation	Epidermolysis Bullosa Simplex With Mottled Pigmentation Ebsmp Speckled Hyperpigmentation With Punctate Palmoplantar Keratoses And Childhood Blistering Ebs-Mp EBS2F Ebs With Mottled Pigmentation Epidermolysis Bullosa Simplex-Mp Speckled Hyperpigmentation, Palmo-Plantar Punctate Keratoses And Childhood Blistering Epidermolysis Bullosa Simplex, With Mottled Pigmentation
Epidermolysis Bullosa Simplex 1a, Generalized Severe	Epidermolysis Bullosa Simplex, Dowling-Meara Type Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type EBS1A Ebsdm Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex, Herpetiformis Ebs-Dm Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type Ebs-Gen Sev Epidermolysis Bullosa Herpetiformis Dowling-Meara Type Generalized Severe Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form Autosomal Dominant Generalized Ebs, Severe Form Epidermolysis Bullosa Simplex Herpetiformis Dm-Ebs Epidermolysis Bullosa Simplex, Generalized Severe Epidermolysis Bullosa Herpetiformis, Dowling-Meara Epidermolysis Bullosa Herpetiformis Dowling-Meara
Hairy Tongue	Overgrowth Of Filiform Papillae Tongue, Hairy
Dowling-Degos Disease	Reticular Pigment Anomaly Of Flexures Dark Dot Disease Reticulate Acropigmentation Of Kitamura Dowling-Degos Kitamura Disease Kitamura Reticulate Acropigmentation Ddd Dowling-Degos-Kitamura Disease Reticular Pigmented Anomaly Of Flexures
Reticulate Acropigmentation Of Kitamura	RAK Acropigmentatio Reticularis Reticulate Pigmentation Of Kitamura Rpk Kitamura Reticulate Acropigmentation Rapk
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Epidermolysis Bullosa Simplex Localized Type	Epidermolysis Bullosa Simplex, Weber-Cockayne Type Weber-Cockayne Syndrome Ebs-Loc Epidermolysis Bullosa Simplex Of Palms And Soles Epidermolysis Bullosa Simplex Weber-Cockayne Type Epidermolysis Bullosa Simplex, Localized Epidermolysis Bullosa Of Hands And Feet Weber-Cockayne Type Epidermolysis Bullosa Simplex Localized Epidermolysis Bullosa Simplex Localized Ebs
Prostate Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Prostate
Ichthyosis, Congenital, Autosomal Recessive 2	Autosomal Recessive Congenital Ichthyosis 2 ARCI2 Ncie1 Ichthyosiform Erythroderma, Congenital Collodion Baby, Self-Healing Ichthyosiform Erythroderma, Nonbullous Congenital, 1, Formerly Ncie1, Formerly Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form, Formerly Brocq Congenital Ichthyosiform Erythroderma Nonbullous Form Nonbullous Congenital Ichthyosiform Erythroderma 1 Cie Ichthyosiform Erythroderma Brocq Congenital Non-Bullous Form Iecn1 Non-Bullous Congenital Ichthyosiform Erythroderma Type 1 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 2 Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Cloacogenic Carcinoma	Cloacogenic Anal Carcinoma
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Epidermolysis Bullosa Dystrophica	Dystrophic Epidermolysis Bullosa Deb Dermolytic Epidermolysis Bullosa Epidermolysis Bullosa, Dermolytic Epidermolysis Bullosa, Dystrophic Epidermolysis Bullosa Dystrophic Dystrophic Eb - [Epidermolysis Bullosa]
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Bullous Skin Disease	Skin Diseases Bullous Skin Diseases, Bullous
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07455	KRT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KRT4	VGNC	VGNC:30732
Rattus norvegicus	KRT4	RGD	RGD:1359272
Felis catus	KRT4	VGNC	VGNC:67990
Mus musculus	KRT4	MGD	MGI:96701
Macaca mulatta	KRT4	VGNC	VGNC:100070
Others	KRT4	NCBI