Cytokeratin 4 Antibody (YA5598)
(Synonyms: CK 4; CK-4; CK4; CYK4; Cytokeratin 4; CytokeRatin-4; CytokeRatin4; FLJ31692; K2C4_HUMAN; K4; KeRatin 4; KeRatin; KeRatin type II cytoskeletal 4; KeRatin-4; KeRatin4; KRT 4; Krt4; type II cytoskeletal 4; Type-II keRatin Kb4)Cytokeratin 4 Antibody (YA5598) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Cytokeratin 4.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
Cytokeratin 4 Antibody (YA5598) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Cytokeratin 4.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
Synthesized peptide derived from human Cytokeratin 4 AA range: 400-534
Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Cytokeratin 4 (KRT4/CK4) is a type II keratin that pairs with KRT13 and is expressed in the spinous layer of non-keratinized stratified squamous epithelium. It assembles into an intermediate filament network to provide structural support and mechanical protection for the mucosal epithelium. Cytokeratin 4 mutation is a major cause of white cavernous nevus, characterized by white cavernous plaques on the oral mucosa. In addition, Cytokeratin 4 is downregulated in oral squamous cell carcinoma, esophageal squamous cell carcinoma and head and neck squamous cell carcinoma, and can serve as a tumor differentiation marker and a potential tumor suppressor[1].
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Expression
Tissue specificity:
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer. -
Isoforms & Post-Translational Modification
Cytokeratin 4: 520 amino acids, molecular weight 56,144 Da.
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Subunit
Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13
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SwissProt ID
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Synonyms
CK 4; CK-4; CK4; CYK4; Cytokeratin 4; CytokeRatin-4; CytokeRatin4; FLJ31692; K2C4_HUMAN; K4; KeRatin 4; KeRatin; KeRatin type II cytoskeletal 4; KeRatin-4; KeRatin4; KRT 4; Krt4; type II cytoskeletal 4; Type-II keRatin Kb4
Documentation
References
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