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KRT25 - keratin 25 Gene

Also Known as ARWH3; KRT25A; KRT24IRS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 147183

About KRT25

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,748,021-40,755,542 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues, 68 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the Cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

KRT25 Products (1)

mRNA	Protein	Name
NM_181534.4	NP_853512.1	keratin, type I cytoskeletal 25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	26902920	GOA
enables protein heterodimerization activity	IMP IMP: Inferred from mutant phenotype	28899683	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	26902920	GOA
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in keratin filament	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT25 Protein Structure

Filament

0
100
200
300
400
450 a.a.

Protein Preferred Names	Protein Names
keratin, type I cytoskeletal 25	CK-25

KRT25 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT25	Q7Z3Z0	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	32296183
Intra	KRT25	Q7Z3Z0	KRT78	Homo sapiens	Q8N1N4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT25 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89691	Keratin 25 Antibody (YA9035)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Woolly Hair, Autosomal Recessive 3	ARWH3 Woolly Hair, Autosomal Recessive 3, With Hypotrichosis Autosomal Recessive Woolly Hair 3 Woolly Hair Autosomal Recessive 3
Hypotrichosis 8	HYPT8 Lah3 Hypotrichosis, Localized, Autosomal Recessive 3 Woolly Hair, Autosomal Recessive 1, With Or Without Hypotrichosis Autosomal Recessive Woolly Hair 1, With Or Without Hypotrichosis Hypotrichosis Localized Autosomal Recessive 3 Woolly Hair Autosomal Recessive 1 With Or Without Hypotrichosis ARWH1 Hypotrichosis, Type 8
Familial Woolly Hair Syndrome	Wooly Hair Familial Wooly Hair Syndrome Hereditary Woolly Hair Syndrome Hereditary Wooly Hair Syndrome Woolly Hair Syndrome With Woolly Hair Wooly Hair Syndrome
Hypotrichosis
Hypotrichosis 7	Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis HYPT7 Hypotrichosis, Localized, Autosomal Recessive 2 Lah2 Ah Total Hypotrichosis, Mari Type Wh/Ht Hypotrichosis, Autosomal Recessive Hypotrichosis, Total, Mari Type Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis Total Mari Type Hypotrichosis Alopecia Universalis Congenita, Mari Type Mari Type Alopecia Universalis Congenita Autosomal Recessive Hypotrichosis Autosomal Recessive Localized Hypotrichosis Autosomal Recessive Woolly Hair With Or Without Hypotrichosis Htl Hypotrichoses Hypotrichosis Lah Alopecia Universalis Congenita Mari Type Hypotrichosis Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 2 Total Hypotrichosis Mari Type Woolly Hair Autosomal Recessive 2 ARWH2 Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis
Hypotrichosis 13	HYPT13 Hypotrichosis With Woolly Hair Hypotrichosis, Type 13
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Combined Oxidative Phosphorylation Deficiency 16	COXPD16 Infantile Hypertrophic Cardiomyopathy Due To Mrpl44 Deficiency Combined Oxidative Phosphorylation Defect Type 16 Combined Oxidative Phosphorylation Deficiency, Type 16
Woolly Hair, Autosomal Dominant	Autosomal Dominant Woolly Hair ADWH Woolly Hair Autosomal Dominant
Naegeli-Franceschetti-Jadassohn Syndrome	Naegeli Syndrome Nfj Syndrome NFJS Reticular Skin Changes, Dental Anomalies, Decreased Function Of Sweat Glands, Strabismus, And Optic Atrophy Naegeli-Franceschetti-Jadassohn Syndrome/Dermatopathia Pigmentosa Reticularis Dpr Franceschetti-Jadassohn Syndrome Nfjs/Dpr
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07449	KRT25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KRT25	RGD	RGD:1359097
Felis catus	KRT25	VGNC	VGNC:108194
Mus musculus	KRT25	MGD	MGI:1918060
Macaca mulatta	KRT25	VGNC	VGNC:74167
Bos taurus	KRT25	VGNC	VGNC:30724
Canis familiaris	KRT25	VGNC	VGNC:49880
Others	KRT25	NCBI