NDOR1 - NADPH dependent diflavin oxidoreductase 1 Gene

Also Known as NR1; CIAE1; bA350O14.9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27158

About NDOR1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,205,700-137,219,361 (from NCBI)

This gene has 6 transcripts (splice variants), 190 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 6.1), bone marrow (RPKM 5.1) and 25 other tissues.

Summary

This gene encodes an NADPH-dependent diflavin reductase that contains both flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) binding domains. The encoded protein catalyzes the transfer of electrons from NADPH through FAD and FMN cofactors to potential redox partners. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

NDOR1 Products (4)

mRNA Protein Name
NM_001144026.3 NP_001137498.1 NADPH-dependent diflavin oxidoreductase 1 isoform a
NM_001144027.3 NP_001137499.1 NADPH-dependent diflavin oxidoreductase 1 isoform d
NM_001144028.3 NP_001137500.1 NADPH-dependent diflavin oxidoreductase 1 isoform c
NM_014434.4 NP_055249.1 NADPH-dependent diflavin oxidoreductase 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables FAD binding IDA
IDA: Inferred from direct assay
10625700 GOA
enables FMN binding IDA
IDA: Inferred from direct assay
10625700 GOA
enables NADP binding IDA
IDA: Inferred from direct assay
15900210 GOA
enables NADPH binding IDA
IDA: Inferred from direct assay
10625700 GOA
enables NADPH-hemoprotein reductase activity IDA
IDA: Inferred from direct assay
10625700 GOA
enables electron transfer activity IDA
IDA: Inferred from direct assay
12631275 GOA
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor IDA
IDA: Inferred from direct assay
12871938 GOA
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
23596212 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16140270 GOA
Biological Process GO Annotation Evidence References Source
involved in electron transport chain IDA
IDA: Inferred from direct assay
10625700 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10625700 GOA
located in cytosol IDA
IDA: Inferred from direct assay
16140270 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDOR1 Protein Structure

Flavodoxin_1

Flavodoxin_1: Flavodoxin (8 - 145)

FAD_binding_1

FAD_binding_1: FAD binding domain (204 - 421)

NAD_binding_1

NAD_binding_1: Oxidoreductase NAD-binding domain (455 - 560)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
Protein Preferred Names Protein Names

NADPH-dependent diflavin oxidoreductase 1

  • NADPH-dependent FMN and FAD-containing oxidoreductase

NDOR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NDOR1 Q9UHB4 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 CENATAC Homo sapiens Q86UT8
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 CENATAC Homo sapiens Q86UT8
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 LMO3 Homo sapiens Q8TAP4-4
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 LMO3 Homo sapiens Q8TAP4-4
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 ZBTB42 Homo sapiens B2RXF5
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 ZBTB42 Homo sapiens B2RXF5
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 PSMB6 Homo sapiens P28072
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 PSMB6 Homo sapiens P28072
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 NLK Homo sapiens Q9UBE8
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 NLK Homo sapiens Q9UBE8
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 GLRX3 Homo sapiens O76003
Anti Tag CoIP
33961781
Intra
NDOR1 Q9UHB4 GLRX3 Homo sapiens O76003
Anti Tag CoIP
27519415
Intra
NDOR1 Q9UHB4 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 HOXB2 Homo sapiens P14652
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 HOXB2 Homo sapiens P14652
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
NDOR1 Q9UHB4 GPS2 Homo sapiens Q13227
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 GPS2 Homo sapiens Q13227
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 KIAA0408 Homo sapiens Q6ZU52
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 KIAA0408 Homo sapiens Q6ZU52
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TCHP Homo sapiens Q9BT92
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 TCHP Homo sapiens Q9BT92
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 TCHP Homo sapiens Q9BT92
Validated Y2H
25416956
Intra
NDOR1 Q9UHB4 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
NDOR1 Q9UHB4 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81
Y2H Prey Pooling
25416956
Intra
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81
Y2H Array
31515488
Intra
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81
Validated Y2H
25416956
Intra
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81
Anti Tag CoIP
27519415
Intra
NDOR1 Q9UHB4 CIAPIN1 Homo sapiens Q6FI81
Anti Tag CoIP
33961781
Intra
NDOR1 Q9UHB4 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
NDOR1 Q9UHB4 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
NDOR1 Q9UHB4 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

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Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09112 NDOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NDOR1 VGNC VGNC:75050
Bos taurus NDOR1 VGNC VGNC:31938
Rattus norvegicus NDOR1 RGD RGD:1308479
Mus musculus NDOR1 MGD MGI:1926047
Felis catus NDOR1 VGNC VGNC:63753
Canis familiaris NDOR1 VGNC VGNC:43677
Others NDOR1 NCBI