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GPS2 - G protein pathway suppressor 2 Gene

Also Known as AMF-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2874

About GPS2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,312,661-7,315,360 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele and 222 orthologues. Ubiquitous expression in testis (RPKM 54.8), spleen (RPKM 24.3) and 25 other tissues.

Summary

This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq, Jul 2008]

GPS2 Products (1)

mRNA	Protein	Name
NM_004489.5	NP_004480.1	G protein pathway suppressor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cyclin binding	IPI IPI: Inferred from physical interaction	15159402	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11931768	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19481530	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	11931768	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	11931768	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11931768	GOA
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	19481530	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19481530	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	29499132	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	29499132	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19858209	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	12628926	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
G protein pathway suppressor 2	GPS-2

GPS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GPS2	Q13227	NDOR1	Homo sapiens	Q9UHB4	Validated Y2H	32296183
Intra	GPS2	Q13227	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	GPS2	Q13227	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	GPS2	Q13227	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	GPS2	Q13227	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	GPS2	Q13227	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	GPS2	Q13227	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	GPS2	Q13227	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GPS2	Q13227	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	GPS2	Q13227	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Array	32296183
Intra	GPS2	Q13227	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	GPS2	Q13227	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	GPS2	Q13227	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	GPS2	Q13227	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	GPS2	Q13227	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	ACTMAP	Homo sapiens	Q5BKX5-3	Validated Y2H	32296183
Intra	GPS2	Q13227	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	GPS2	Q13227	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	GPS2	Q13227	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	GPS2	Q13227	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	GPS2	Q13227	SMUG1	Homo sapiens	Q53HV7-2	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	SMUG1	Homo sapiens	Q53HV7-2	Validated Y2H	32296183
Intra	GPS2	Q13227	SMUG1	Homo sapiens	Q53HV7-2	Y2H Array	32296183
Intra	GPS2	Q13227	UBTD2	Homo sapiens	Q8WUN7	Validated Y2H	32296183
Intra	GPS2	Q13227	TBL1X	Homo sapiens	O60907-2	Pull Down	21240272
Intra	GPS2	Q13227	TBL1X	Homo sapiens	O60907-2	Anti Tag CoIP	28514442
Intra	GPS2	Q13227	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	GPS2	Q13227	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	GPS2	Q13227	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	17895379
Intra	GPS2	Q13227	HDAC1	Homo sapiens	Q13547	Pull Down	17895379
Intra	GPS2	Q13227	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	GPS2	Q13227	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	GPS2	Q13227	HNRNPH1	Homo sapiens	P31943	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	HNRNPH1	Homo sapiens	P31943	Y2H Array	32296183
Intra	GPS2	Q13227	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	GPS2	Q13227	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	GPS2	Q13227	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	GPS2	Q13227	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	GPS2	Q13227	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	GPS2	Q13227	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	GPS2	Q13227	ATF4	Homo sapiens	P18848	Y2H Array	29892012
Intra	GPS2	Q13227	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	25416956
Intra	GPS2	Q13227	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	ATF5	Homo sapiens	Q9Y2D1	Validated Y2H	32296183
Intra	GPS2	Q13227	ATF5	Homo sapiens	Q9Y2D1	Y2H Array	32296183
Intra	GPS2	Q13227	ATF5	Homo sapiens	Q9Y2D1	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	GPS2	Q13227	HDAC3	Homo sapiens	O15379	Pull Down	17895379
Intra	GPS2	Q13227	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	33961781
Intra	GPS2	Q13227	HDAC3	Homo sapiens	O15379	Anti Tag CoIP	17895379
Intra	GPS2	Q13227	SESTD1	Homo sapiens	Q86VW0	Y2H Array	32296183
Intra	GPS2	Q13227	SESTD1	Homo sapiens	Q86VW0	Y2H Prey Pooling	25416956
Intra	GPS2	Q13227	SESTD1	Homo sapiens	Q86VW0	Validated Y2H	25416956
Intra	GPS2	Q13227	SESTD1	Homo sapiens	Q86VW0	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	SESTD1	Homo sapiens	Q86VW0	Validated Y2H	32296183
Intra	GPS2	Q13227	SESTD1	Homo sapiens	Q86VW0	Y2H Array	25416956
Intra	GPS2	Q13227	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	GPS2	Q13227	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	GPS2	Q13227	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	GPS2	Q13227	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	GPS2	Q13227	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	GPS2	Q13227	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	TRIP6	Homo sapiens	Q15654	Validated Y2H	32296183
Intra	GPS2	Q13227	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	GPS2	Q13227	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	INTS11	Homo sapiens	Q5TA45	Validated Y2H	32296183
Intra	GPS2	Q13227	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	GPS2	Q13227	MAP3K7CL	Homo sapiens	P57077	Y2H Pooling	16189514
Intra	GPS2	Q13227	RALBP1	Homo sapiens	Q15311	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	RALBP1	Homo sapiens	Q15311	Anti Tag CoIP	33961781
Intra	GPS2	Q13227	RALBP1	Homo sapiens	Q15311	Validated Y2H	32296183
Intra	GPS2	Q13227	RALBP1	Homo sapiens	Q15311	Y2H Array	25416956
Intra	GPS2	Q13227	RALBP1	Homo sapiens	Q15311	Y2H Array	32296183
Intra	GPS2	Q13227	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183
Intra	GPS2	Q13227	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	GPS2	Q13227	NCOR2	Homo sapiens	Q9Y618	NMR	21240272
Intra	GPS2	Q13227	NCOR2	Homo sapiens	Q9Y618	GMS	21240272
Intra	GPS2	Q13227	NCOR2	Homo sapiens	Q9Y618	Anti Tag CoIP	33961781
Intra	GPS2	Q13227	NCOR2	Homo sapiens	Q9Y618	Pull Down	21240272
Intra	GPS2	Q13227	POU2AF1	Homo sapiens	Q16633	Validated Y2H	32296183
Intra	GPS2	Q13227	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	GPS2	Q13227	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	GPS2	Q13227	KRT31	Homo sapiens	Q15323	MAPPIT	25416956
Intra	GPS2	Q13227	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	GPS2	Q13227	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	GPS2	Q13227	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	GPS2	Q13227	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	GPS2	Q13227	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183
Intra	GPS2	Q13227	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	GPS2	Q13227	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183
Cross	GPS2	Q13227	Q9WMX2-PRO_0000037551	Hepatitis C virus	Q9WMX2-PRO_0000037551	Pull Down	18985028
Cross	GPS2	Q13227	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Liposarcoma	Lipomatous Cancer
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05758	GPS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20280	Gps2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26788	Gps2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPS2	MGD	MGI:1891751
Felis catus	GPS2	VGNC	VGNC:99074
Canis familiaris	GPS2	VGNC	VGNC:41456
Macaca mulatta	GPS2	VGNC	VGNC:99156
Rattus norvegicus	GPS2	RGD	RGD:1562746
Bos taurus	GPS2	VGNC	VGNC:29613
Others	GPS2	NCBI