INTS11 - integrator complex subunit 11 Gene

Homo sapiens

Also known as RC68; INT11; RC-68; CPSF3L; CPSF73L

Gene ID: 54973 | Gene type: protein coding

About INTS11

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,311,600-1,324,660 (from NCBI)

This gene has 49 transcripts (splice variants), 202 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 35.0), endometrium (RPKM 21.3) and 25 other tissues.

Summary

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS11 Products(5)

mRNA	Protein	Name
NM_001256456.2	NP_001243385.1	integrator complex subunit 11 isoform 1
NM_001256460.2	NP_001243389.1	integrator complex subunit 11 isoform 3
NM_001256462.2	NP_001243391.1	integrator complex subunit 11 isoform 4
NM_001256463.2	NP_001243392.1	integrator complex subunit 11 isoform 5
NM_017871.6	NP_060341.2	integrator complex subunit 11 isoform 2

INTS11 Protein Structure

Lactamase_B

Beta-Casp

RMMBL

0
100
200
300
400
500
600 a.a.

Protein Preferred Names

Protein Names

integrator complex subunit 11

CPSF3-like protein

Related Diseases

Diseases

Alias

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06852	INTS11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INTS11	RGD	RGD:1306841
Canis familiaris	INTS11	VGNC	VGNC:42047
Felis catus	INTS11	VGNC	VGNC:62939
Macaca mulatta	INTS11	VGNC	VGNC:73658
Mus musculus	INTS11	MGD	MGI:1919207

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