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INTS11 - integrator complex subunit 11 Gene

Also Known as RC68; INT11; RC-68; CPSF3L; CPSF73L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54973

About INTS11

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,311,600-1,324,660 (from NCBI)

This gene has 49 transcripts (splice variants), 202 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 35.0), endometrium (RPKM 21.3) and 25 other tissues.

Summary

The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS11 Products (5)

mRNA	Protein	Name
NM_001256456.2	NP_001243385.1	integrator complex subunit 11 isoform 1
NM_001256460.2	NP_001243389.1	integrator complex subunit 11 isoform 3
NM_001256462.2	NP_001243391.1	integrator complex subunit 11 isoform 4
NM_001256463.2	NP_001243392.1	integrator complex subunit 11 isoform 5
NM_017871.6	NP_060341.2	integrator complex subunit 11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	16239144	GOA
contributes to protein binding	IPI IPI: Inferred from physical interaction	16239144	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in snRNA processing	IDA IDA: Inferred from direct assay	16239144	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23904267	GOA
part of integrator complex	IDA IDA: Inferred from direct assay	16239144	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23904267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS11 Protein Structure

Lactamase_B

Beta-Casp

RMMBL

0
100
200
300
400
500
600 a.a.

Protein Preferred Names	Protein Names
integrator complex subunit 11	CPSF3-like protein

INTS11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INTS11	Q5TA45	TCF7L2	Homo sapiens	Q9NQB0-10	Validated Y2H	32296183
Intra	INTS11	Q5TA45	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	INTS11	Q5TA45	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	INTS11	Q5TA45	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
Intra	INTS11	Q5TA45	SPIC	Homo sapiens	Q8N5J4	Validated Y2H	32296183
Intra	INTS11	Q5TA45	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	INTS11	Q5TA45	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	INTS11	Q5TA45	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	INTS11	Q5TA45	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	INTS11	Q5TA45	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	INTS11	Q5TA45	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	GMS	32647223
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	Chromatography	36180473
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	X-Ray Diffraction	28396433
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	Crosslink	33548203
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	3D-EM	33548203
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	Crosslink	32647223
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	Pull Down	33548203
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	Y2H	28396433
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	GMS	33548203
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	TAP	24981860
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	GMS	36180473
Intra	INTS11	Q5TA45	INTS9	Homo sapiens	Q9NV88	Anti Tag CoIP	28396433
Intra	INTS11	Q5TA45	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	INTS11	Q5TA45	KRTAP26-1	Homo sapiens	Q6PEX3	Validated Y2H	32296183
Intra	INTS11	Q5TA45	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	INTS11	Q5TA45	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183
Intra	INTS11	Q5TA45	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	INTS11	Q5TA45	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183
Intra	INTS11	Q5TA45	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06852	INTS11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INTS11	RGD	RGD:1306841
Canis familiaris	INTS11	VGNC	VGNC:42047
Felis catus	INTS11	VGNC	VGNC:62939
Macaca mulatta	INTS11	VGNC	VGNC:73658
Mus musculus	INTS11	MGD	MGI:1919207
Others	INTS11	NCBI