INTS9 - integrator complex subunit 9 Gene

Also Known as INT9; RC74; CPSF2L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55756

About INTS9

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,767,661-28,889,969 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.2), adrenal (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

INTS9 Products (4)

mRNA	Protein	Name
NM_001145159.3	NP_001138631.1	integrator complex subunit 9 isoform 2
NM_001172562.2	NP_001166033.1	integrator complex subunit 9 isoform 3
NM_001363038.2	NP_001349967.1	integrator complex subunit 9 isoform 4
NM_018250.4	NP_060720.2	integrator complex subunit 9 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16239144	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	36641752	GOA
involved in snRNA processing	IDA IDA: Inferred from direct assay	16239144	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of integrator complex	IDA IDA: Inferred from direct assay	16239144	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23904267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS9 Protein Structure

Beta-Casp

0
200
400
600
658 a.a.

Protein Preferred Names	Protein Names
integrator complex subunit 9	protein related to CPSF subunits of 74 kDa

INTS9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	INTS9	Q9NV88	INTS4	Homo sapiens	Q96HW7	Pull Down	33548203
Intra	INTS9	Q9NV88	INTS4	Homo sapiens	Q96HW7	Anti Tag CoIP	33548203
Intra	INTS9	Q9NV88	INTS4	Homo sapiens	Q96HW7	Anti Tag CoIP	33961781
Intra	INTS9	Q9NV88	INTS11	Homo sapiens	Q5TA45	Anti Tag CoIP	33961781
Intra	INTS9	Q9NV88	INTS11	Homo sapiens	Q5TA45	Pull Down	33548203
Intra	INTS9	Q9NV88	INTS11	Homo sapiens	Q5TA45	Anti Tag CoIP	33548203

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immature Cataract	Incipient Cataract Incipient Senile Cataract Water Clefts
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06858	INTS9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	INTS9	VGNC	VGNC:30234
Rattus norvegicus	INTS9	RGD	RGD:1311539
Macaca mulatta	INTS9	VGNC	VGNC:73654
Mus musculus	INTS9	MGD	MGI:1098533
Canis familiaris	INTS9	VGNC	VGNC:42058
Felis catus	INTS9	VGNC	VGNC:62949
Others	INTS9	NCBI