2. Gene
  3. INTS9 - integrator complex subunit 9 Gene

INTS9 - integrator complex subunit 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as INT9; RC74; CPSF2L

Gene ID: 55756 | Gene type: protein coding

About INTS9

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:28,767,661-28,889,969 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 6.2), adrenal (RPKM 5.5) and 25 other tissues.

Summary

This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

INTS9 Products(4)

mRNA Protein Name
NM_001145159.3 NP_001138631.1 integrator complex subunit 9 isoform 2
NM_001172562.2 NP_001166033.1 integrator complex subunit 9 isoform 3
NM_001363038.2 NP_001349967.1 integrator complex subunit 9 isoform 4
NM_018250.4 NP_060720.2 integrator complex subunit 9 isoform 1

INTS9 Protein Structure

Beta-Casp

Beta-Casp: Beta-Casp domain (307 - 426)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
Protein Preferred Names Protein Names

integrator complex subunit 9

protein related to CPSF subunits of 74 kDa

Related Diseases

Diseases Alias
Immature Cataract

Incipient Cataract

Incipient Senile Cataract

Water Clefts
Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06858 INTS9 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INTS9 VGNC VGNC:30234
Rattus norvegicus INTS9 RGD RGD:1311539
Macaca mulatta INTS9 VGNC VGNC:73654
Mus musculus INTS9 MGD MGI:1098533
Canis familiaris INTS9 VGNC VGNC:42058
Felis catus INTS9 VGNC VGNC:62949