INTS4 - integrator complex subunit 4 Gene

Also Known as INT4; MST093

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 92105

Summary

INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in lymph node (RPKM 4.0), appendix (RPKM 3.5) and 25 other tissues.

INTS4 Products (1)

mRNA Protein Name
NM_033547.4 NP_291025.3 integrator complex subunit 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239144 GOA
Biological Process GO Annotation Evidence References Source
involved in snRNA processing IDA
IDA: Inferred from direct assay
16239144 GOA
Cellular Component GO Annotation Evidence References Source
part of integrator complex IDA
IDA: Inferred from direct assay
16239144 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23904267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INTS4 Q96HW7 ZMIZ2 Homo sapiens Q8NF64-2
Y2H Array
25416956
Intra
INTS4 Q96HW7 INTS9 Homo sapiens Q9NV88
Anti Tag CoIP
33548203
Intra
INTS4 Q96HW7 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra
INTS4 Q96HW7 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
25416956
Intra
INTS4 Q96HW7 HGS Homo sapiens O14964
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164133 SM00465 Inhibitor / Unkown