LENG8 - leukocyte receptor cluster member 8 Gene

Also Known as pp13842

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114823

About LENG8

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,449,199-54,462,016 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 188 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 65.5), endometrium (RPKM 49.9) and 24 other tissues.

Summary

Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

LENG8 Products (6)

mRNA Protein Name
NM_001375638.1 NP_001362567.1 leukocyte receptor cluster member 8 isoform 1
NM_001375639.1 NP_001362568.1 leukocyte receptor cluster member 8 isoform 2
NM_001375640.1 NP_001362569.1 leukocyte receptor cluster member 8 isoform 1
NM_001375641.1 NP_001362570.1 leukocyte receptor cluster member 8 isoform 1
NM_001411063.1 NP_001397992.1 leukocyte receptor cluster member 8 isoform 4
NM_052925.4 NP_443157.1 leukocyte receptor cluster member 8 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239144 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LENG8 Protein Structure

SAC3_GANP

SAC3_GANP: SAC3/GANP family (567 - 763)

  • 0
  • 200
  • 400
  • 600
  • 800 a.a.
Protein Preferred Names Protein Names

leukocyte receptor cluster member 8

  • leukocyte receptor cluster (LRC) member 8

LENG8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LENG8 Q96PV6 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra
LENG8 Q96PV6 PCID2 Homo sapiens Q5JVF3
Y2H Array
32296183
Intra
LENG8 Q96PV6 PCID2 Homo sapiens Q5JVF3
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 PER2 Homo sapiens O15055
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 PER2 Homo sapiens O15055
Y2H Array
32296183
Intra
LENG8 Q96PV6 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
LENG8 Q96PV6 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
LENG8 Q96PV6 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
LENG8 Q96PV6 CPSF7 Homo sapiens Q8N684-3
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 CPSF7 Homo sapiens Q8N684-3
Y2H Array
32296183
Intra
LENG8 Q96PV6 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
LENG8 Q96PV6 ATN1 Homo sapiens Q86V38
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 ATN1 Homo sapiens Q86V38
Y2H Array
32296183
Intra
LENG8 Q96PV6 VGLL3 Homo sapiens A8MV65-2
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 VGLL3 Homo sapiens A8MV65-2
Y2H Array
32296183
Intra
LENG8 Q96PV6 CIMIP2B Homo sapiens A8MTA8-2
Y2H Array
32296183
Intra
LENG8 Q96PV6 CIMIP2B Homo sapiens A8MTA8-2
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 C10orf55 Homo sapiens Q5SWW7
Y2H Array
32296183
Intra
LENG8 Q96PV6 C10orf55 Homo sapiens Q5SWW7
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 CAMK2A Homo sapiens Q9UQM7
Validated Y2H
32296183
Intra
LENG8 Q96PV6 CAMK2A Homo sapiens Q9UQM7
Y2H Array
32296183
Intra
LENG8 Q96PV6 CAMK2A Homo sapiens Q9UQM7
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 SOCS7 Homo sapiens O14512
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 SOCS7 Homo sapiens O14512
Y2H Array
32296183
Intra
LENG8 Q96PV6 MIA3 Homo sapiens Q5JRA6
Y2H Array
32296183
Intra
LENG8 Q96PV6 MIA3 Homo sapiens Q5JRA6
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TSG101 Homo sapiens Q99816
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Intra
LENG8 Q96PV6 TSG101 Homo sapiens Q99816
Y2H Array
32296183
Intra
LENG8 Q96PV6 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
LENG8 Q96PV6 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
LENG8 Q96PV6 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
LENG8 Q96PV6 ANKHD1 Homo sapiens Q8IWG5
Y2H Array
32296183
Intra
LENG8 Q96PV6 ANKHD1 Homo sapiens Q8IWG5
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TFG Homo sapiens Q92734
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TFG Homo sapiens Q92734
Y2H Array
32296183
Intra
LENG8 Q96PV6 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra
LENG8 Q96PV6 TRAF4 Homo sapiens Q9BUZ4
Y2H Array
32296183
Intra
LENG8 Q96PV6 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
LENG8 Q96PV6 GSE1 Homo sapiens Q14687
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 GSE1 Homo sapiens Q14687
Y2H Array
32296183
Intra
LENG8 Q96PV6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
LENG8 Q96PV6 COG2 Homo sapiens Q14746
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 COG2 Homo sapiens Q14746
Y2H Array
32296183
Intra
LENG8 Q96PV6 HNRNPM Homo sapiens P52272
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 HNRNPM Homo sapiens P52272
Y2H Array
32296183
Intra
LENG8 Q96PV6 MYOZ3 Homo sapiens Q8TDC0
Y2H Array
32296183
Intra
LENG8 Q96PV6 MYOZ3 Homo sapiens Q8TDC0
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 SNRPA Homo sapiens P09012
Y2H Array
25416956
Intra
LENG8 Q96PV6 SNRPA Homo sapiens P09012
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 SNRPA Homo sapiens P09012
Y2H Array
32296183
Intra
LENG8 Q96PV6 MSX2 Homo sapiens P35548
Y2H Array
32296183
Intra
LENG8 Q96PV6 MSX2 Homo sapiens P35548
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
LENG8 Q96PV6 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
LENG8 Q96PV6 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
LENG8 Q96PV6 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
LENG8 Q96PV6 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
LENG8 Q96PV6 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
LENG8 Q96PV6 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
LENG8 Q96PV6 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
LENG8 Q96PV6 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
LENG8 Q96PV6 HMGXB4 Homo sapiens Q9UGU5
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 HMGXB4 Homo sapiens Q9UGU5
Validated Y2H
32296183
Intra
LENG8 Q96PV6 HMGXB4 Homo sapiens Q9UGU5
Y2H Array
32296183
Intra
LENG8 Q96PV6 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
LENG8 Q96PV6 MAPK1IP1L Homo sapiens Q8NDC0
Y2H Array
19060904
Intra
LENG8 Q96PV6 MAPK1IP1L Homo sapiens Q8NDC0
Y2H Pooling
19060904
Intra
LENG8 Q96PV6 MAPK1IP1L Homo sapiens Q8NDC0
Y2H Array
32296183
Intra
LENG8 Q96PV6 MAPK1IP1L Homo sapiens Q8NDC0
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 CFAP53 Homo sapiens Q96M91
Y2H Array
32296183
Intra
LENG8 Q96PV6 CFAP53 Homo sapiens Q96M91
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
LENG8 Q96PV6 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
LENG8 Q96PV6 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
LENG8 Q96PV6 INTS11 Homo sapiens Q5TA45
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 INTS11 Homo sapiens Q5TA45
Y2H Array
32296183
Intra
LENG8 Q96PV6 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
LENG8 Q96PV6 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
LENG8 Q96PV6 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
LENG8 Q96PV6 IKBKG Homo sapiens Q9Y6K9
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 IKBKG Homo sapiens Q9Y6K9
Y2H Array
32296183
Intra
LENG8 Q96PV6 IKBKG Homo sapiens Q9Y6K9
Validated Y2H
32296183
Intra
LENG8 Q96PV6 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
LENG8 Q96PV6 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra
LENG8 Q96PV6 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra
LENG8 Q96PV6 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07591 LENG8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LENG8 MGD MGI:2142195
Bos taurus LENG8 VGNC VGNC:30839
Rattus norvegicus LENG8 RGD RGD:1306180
Macaca mulatta LENG8 VGNC VGNC:74047
Canis familiaris LENG8 VGNC VGNC:42636
Felis catus LENG8 VGNC VGNC:63213
Others LENG8 NCBI