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GSE1 - Gse1 coiled-coil protein Gene

Also Known as CRHSP24; KIAA0182

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23199

About GSE1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,169,512-85,676,200 (from NCBI)

This gene has 16 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in placenta (RPKM 7.8), fat (RPKM 7.8) and 25 other tissues.

Summary

This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast Cancer and enhanced expression of the encoded protein has been observed in breast Cancer patients. [provided by RefSeq, May 2017]

GSE1 Products (3)

mRNA	Protein	Name
NM_001134473.3	NP_001127945.1	genetic suppressor element 1 isoform 2
NM_001278184.3	NP_001265113.1	genetic suppressor element 1 isoform 3
NM_014615.5	NP_055430.1	genetic suppressor element 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSE1 Protein Structure

DUF3736

0
200
400
600
800
1000
1217 a.a.

Protein Preferred Names	Protein Names
genetic suppressor element 1	CTC-786C10.1

GSE1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GSE1	Q14687	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	GSE1	Q14687	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	GSE1	Q14687	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	GSE1	Q14687	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	GSE1	Q14687	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GSE1	Q14687	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	GSE1	Q14687	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	GSE1	Q14687	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	GSE1	Q14687	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	RCOR3	Homo sapiens	Q9P2K3	Y2H Pooling	16189514
Intra	GSE1	Q14687	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	GSE1	Q14687	CFAP206	Homo sapiens	Q8IYR0	Validated Y2H	25416956
Intra	GSE1	Q14687	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	32296183
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	32296183
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	GSE1	Q14687	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intraventricular Meningioma
Adult Medulloblastoma	Adult Brain Medulloblastoma Medulloblastoma, Adult
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Basal Cell Nevus Syndrome	Nevoid Basal Cell Carcinoma Syndrome Gorlin Syndrome Nbccs BCNS Gorlin-Goltz Syndrome Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies Cerebral Gigantism Jaw Cysts Cramer Niederdellmann Syndrome Gorlin Syndrome Or Gorlin-Goltz Syndrome Naevoid Basal Cell Carcinoma Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05859	GSE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GSE1	VGNC	VGNC:41527
Mus musculus	GSE1	MGD	MGI:1098275
Bos taurus	GSE1	VGNC	VGNC:55049
Macaca mulatta	GSE1	VGNC	VGNC:73254
Felis catus	GSE1	VGNC	VGNC:108362
Rattus norvegicus	GSE1	RGD	RGD:1562686
Others	GSE1	NCBI