PCID2 - PCI domain containing 2 Gene

Also Known as F10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55795

About PCID2

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,165,002-113,208,669 (from NCBI)

This gene has 16 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in testis (RPKM 6.6), ovary (RPKM 4.5) and 25 other tissues.

Summary

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast Cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

PCID2 Products (14)

mRNA Protein Name
NM_001127202.4 NP_001120674.1 PCI domain-containing protein 2 isoform 1
NM_001127203.4 NP_001120675.1 PCI domain-containing protein 2 isoform 1
NM_001258213.3 NP_001245142.1 PCI domain-containing protein 2 isoform 3
NM_001320655.2 NP_001307584.1 PCI domain-containing protein 2 isoform 3
NM_001320656.2 NP_001307585.1 PCI domain-containing protein 2 isoform 2
NM_001320657.2 NP_001307586.1 PCI domain-containing protein 2 isoform 4
NM_001320659.2 NP_001307588.1 PCI domain-containing protein 2 isoform 5
NM_001320660.2 NP_001307589.1 PCI domain-containing protein 2 isoform 6
NM_001353091.2 NP_001340020.1 PCI domain-containing protein 2 isoform 7
NM_001353092.2 NP_001340021.1 PCI domain-containing protein 2 isoform 3
NM_001353093.2 NP_001340022.1 PCI domain-containing protein 2 isoform 7
NM_001353094.2 NP_001340023.1 PCI domain-containing protein 2 isoform 7
NM_001353095.2 NP_001340024.1 PCI domain-containing protein 2 isoform 8
NM_018386.5 NP_060856.2 PCI domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22343721 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20870947 GOA
involved in negative regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
20870947 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20870947 GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: Inferred from mutant phenotype
20870947 GOA
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
20870947 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23591820 GOA
part of nuclear pore nuclear basket IDA
IDA: Inferred from direct assay
23591820 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23591820 GOA
part of transcription export complex 2 IDA
IDA: Inferred from direct assay
23591820 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCID2 Protein Structure

PCI

PCI: PCI domain (278 - 388)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
Protein Preferred Names Protein Names

PCI domain-containing protein 2

  • CSN12-like protein

PCID2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PCID2 Q5JVF3 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra
PCID2 Q5JVF3 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Intra
PCID2 Q5JVF3 SEM1 Homo sapiens P60896
Y2H Prey Pooling
32296183
Intra
PCID2 Q5JVF3 SEM1 Homo sapiens P60896
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10150 PCID2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PCID2 VGNC VGNC:44305
Mus musculus PCID2 MGD MGI:2443003
Felis catus PCID2 VGNC VGNC:64069
Macaca mulatta PCID2 VGNC VGNC:75680
Rattus norvegicus PCID2 RGD RGD:1307041
Bos taurus PCID2 VGNC VGNC:32629
Others PCID2 NCBI