SOCS7 - suppressor of cytokine signaling 7 Gene

Also Known as NAP4; NCKAP4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30837

About SOCS7

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,351,844-38,405,593 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 252 orthologues and 7 paralogues. Broad expression in testis (RPKM 18.1), brain (RPKM 7.5) and 24 other tissues.

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within several processes, including brain development; fat cell differentiation; and Insulin Receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SOCS7 Products (1)

mRNA Protein Name
NM_014598.4 NP_055413.2 suppressor of cytokine signaling 7

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17803907 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
17803907 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

suppressor of cytokine signaling 7

  • NAP-4

SOCS7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SOCS7 O14512 NSMF Homo sapiens Q6X4W1-2
Validated Y2H
32296183
Intra
SOCS7 O14512 SORBS2 Homo sapiens O94875-10
Validated Y2H
32296183
Intra
SOCS7 O14512 MISP Homo sapiens Q8IVT2
Validated Y2H
32296183
Intra
SOCS7 O14512 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra
SOCS7 O14512 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
SOCS7 O14512 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
SOCS7 O14512 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SOCS7 O14512 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SOCS7 O14512 GRB2 Homo sapiens P62993
Validated Y2H
32296183
Intra
SOCS7 O14512 YES1 Homo sapiens P07947
Validated Y2H
32296183
Intra
SOCS7 O14512 NCK2 Homo sapiens O43639
Validated Y2H
32296183
Intra
SOCS7 O14512 NCK2 Homo sapiens O43639
Anti Tag CoIP
33961781
Intra
SOCS7 O14512 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
SOCS7 O14512 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
SOCS7 O14512 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
SOCS7 O14512 HSPB8 Homo sapiens Q9UJY1
Validated Y2H
32296183
Intra
SOCS7 O14512 HSPB8 Homo sapiens Q9UJY1
Y2H Array
32296183
Intra
SOCS7 O14512 HSPB8 Homo sapiens Q9UJY1
Y2H Prey Pooling
32296183
Intra
SOCS7 O14512 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra
SOCS7 O14512 SORBS3 Homo sapiens O60504
Validated Y2H
32296183
Intra
SOCS7 O14512 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
SOCS7 O14512 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
SOCS7 O14512 GAS2L2 Homo sapiens Q8NHY3
Validated Y2H
32296183
Intra
SOCS7 O14512 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Uvulitis

  • Acute Uvulitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13555 SOCS4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13558 SOCS7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SOCS7 MGD MGI:2651588
Canis familiaris SOCS7 VGNC VGNC:55821
Macaca mulatta SOCS7 VGNC VGNC:77792
Felis catus SOCS7 VGNC VGNC:65566
Rattus norvegicus SOCS7 RGD RGD:1307720
Bos taurus SOCS7 VGNC VGNC:35125
Others SOCS7 NCBI