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MISP - mitotic spindle positioning Gene

Also Known as MISP1; C19orf21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 126353

About MISP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:748,438-764,318 (from NCBI)

This gene has 2 transcripts (splice variants), 136 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 92.0), duodenum (RPKM 77.1) and 6 other tissues.

Summary

The protein encoded by this gene is an actin-bundling protein involved in determining cell morphology and mitotic progression. The encoded protein is required for the proper positioning of the mitotic spindle. Two transcript variants, one protein-coding and the Other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2016]

MISP Products (1)

mRNA	Protein	Name
NM_173481.4	NP_775752.1	mitotic interactor and substrate of PLK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	23509069	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23509069	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	23574715	GOA
involved in establishment of centrosome localization	IMP IMP: Inferred from mutant phenotype	23509069	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	23509069	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	23574715	GOA
involved in organelle localization	IMP IMP: Inferred from mutant phenotype	23574715	GOA
involved in regulation of protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	23509069	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IMP IMP: Inferred from mutant phenotype	23574715	GOA
colocalizes with cortical actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	23509069	GOA
colocalizes with focal adhesion	IMP IMP: Inferred from mutant phenotype	23509069	GOA
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	23574715	GOA
colocalizes with mitotic spindle astral microtubule end	IMP IMP: Inferred from mutant phenotype	23509069	GOA
located in spindle pole centrosome	IMP IMP: Inferred from mutant phenotype	23574715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MISP Protein Structure

AKAP2_C

0
200
400
600
679 a.a.

Protein Preferred Names	Protein Names
mitotic interactor and substrate of PLK1	caprice

MISP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MISP	Q8IVT2	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	MISP	Q8IVT2	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	MISP	Q8IVT2	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	DPH2	Homo sapiens	Q9BQC3	Validated Y2H	32296183
Intra	MISP	Q8IVT2	DPH2	Homo sapiens	Q9BQC3	Y2H Array	32296183
Intra	MISP	Q8IVT2	DPH2	Homo sapiens	Q9BQC3	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	MISP	Q8IVT2	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	RIBC1	Homo sapiens	Q8N443	Y2H Array	32296183
Intra	MISP	Q8IVT2	RIBC1	Homo sapiens	Q8N443	Validated Y2H	32296183
Intra	MISP	Q8IVT2	RIBC1	Homo sapiens	Q8N443	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
Intra	MISP	Q8IVT2	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	MISP	Q8IVT2	EZR	Homo sapiens	P15311	Anti Tag CoIP	28514442
Intra	MISP	Q8IVT2	EZR	Homo sapiens	P15311	Anti Tag CoIP	33961781
Intra	MISP	Q8IVT2	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	MISP	Q8IVT2	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	MISP	Q8IVT2	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	MISP	Q8IVT2	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	MISP	Q8IVT2	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
Intra	MISP	Q8IVT2	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	BOLL	Homo sapiens	Q8N9W6-4	Validated Y2H	32296183
Intra	MISP	Q8IVT2	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	SPATC1L	Homo sapiens	Q9H0A9-2	Validated Y2H	32296183
Intra	MISP	Q8IVT2	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Array	32296183
Intra	MISP	Q8IVT2	MORN5	Homo sapiens	Q5VZ52	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	MORN5	Homo sapiens	Q5VZ52	Y2H Array	32296183
Intra	MISP	Q8IVT2	SOCS7	Homo sapiens	O14512	Y2H Array	32296183
Intra	MISP	Q8IVT2	SOCS7	Homo sapiens	O14512	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PRR5L	Homo sapiens	Q6MZQ0	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PRR5L	Homo sapiens	Q6MZQ0	Y2H Array	32296183
Intra	MISP	Q8IVT2	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	MISP	Q8IVT2	SF3A2	Homo sapiens	Q15428	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	SF3A2	Homo sapiens	Q15428	Y2H Array	32296183
Intra	MISP	Q8IVT2	CRBN	Homo sapiens	Q96SW2	Validated Y2H	32296183
Intra	MISP	Q8IVT2	CRBN	Homo sapiens	Q96SW2	Y2H Array	32296183
Intra	MISP	Q8IVT2	CRBN	Homo sapiens	Q96SW2	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	MISP	Q8IVT2	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	MISP	Q8IVT2	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H Array	32296183
Intra	MISP	Q8IVT2	MAP1LC3C	Homo sapiens	Q9BXW4	Validated Y2H	32296183
Intra	MISP	Q8IVT2	MAP1LC3C	Homo sapiens	Q9BXW4	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	CDPF1	Homo sapiens	Q6NVV7	Y2H Array	32296183
Intra	MISP	Q8IVT2	CDPF1	Homo sapiens	Q6NVV7	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PNMA2	Homo sapiens	Q9UL42	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PNMA2	Homo sapiens	Q9UL42	Validated Y2H	32296183
Intra	MISP	Q8IVT2	PNMA2	Homo sapiens	Q9UL42	Y2H Array	32296183
Intra	MISP	Q8IVT2	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	MISP	Q8IVT2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	MISP	Q8IVT2	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	MISP	Q8IVT2	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PIH1D1	Homo sapiens	Q9NWS0	Y2H Array	32296183
Intra	MISP	Q8IVT2	PIH1D1	Homo sapiens	Q9NWS0	Validated Y2H	32296183
Intra	MISP	Q8IVT2	PIH1D1	Homo sapiens	Q9NWS0	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	VBP1	Homo sapiens	P61758	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	VBP1	Homo sapiens	P61758	Y2H Array	32296183
Intra	MISP	Q8IVT2	SPATS1	Homo sapiens	Q496A3	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	SPATS1	Homo sapiens	Q496A3	Y2H Array	32296183
Intra	MISP	Q8IVT2	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	MISP	Q8IVT2	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	MISP	Q8IVT2	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	MISP	Q8IVT2	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	MISP	Q8IVT2	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	MISP	Q8IVT2	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	MISP	Q8IVT2	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	MISP	Q8IVT2	SNW1	Homo sapiens	Q13573	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	SNW1	Homo sapiens	Q13573	Y2H Array	32296183
Intra	MISP	Q8IVT2	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	FHL2	Homo sapiens	Q14192	Y2H Array	32296183
Intra	MISP	Q8IVT2	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	MISP	Q8IVT2	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	MISP	Q8IVT2	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	TERF1	Homo sapiens	P54274-2	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	TERF1	Homo sapiens	P54274-2	Y2H Array	32296183
Intra	MISP	Q8IVT2	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	MISP	Q8IVT2	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	MISP	Q8IVT2	HSPB8	Homo sapiens	Q9UJY1	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	HSPB8	Homo sapiens	Q9UJY1	Validated Y2H	32296183
Intra	MISP	Q8IVT2	HSPB8	Homo sapiens	Q9UJY1	Y2H Array	32296183
Intra	MISP	Q8IVT2	HSPB2	Homo sapiens	Q16082	Y2H Array	32296183
Intra	MISP	Q8IVT2	HSPB2	Homo sapiens	Q16082	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	MISP	Q8IVT2	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	MISP	Q8IVT2	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	MISP	Q8IVT2	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	MISP	Q8IVT2	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	32296183
Intra	MISP	Q8IVT2	ENKD1	Homo sapiens	Q9H0I2	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	MISP	Q8IVT2	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	MISP	Q8IVT2	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	MISP	Q8IVT2	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	MISP	Q8IVT2	LMO1	Homo sapiens	P25800	Y2H Array	32296183
Intra	MISP	Q8IVT2	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	IRAK1BP1	Homo sapiens	Q5VVH5	Y2H Array	32296183
Intra	MISP	Q8IVT2	IRAK1BP1	Homo sapiens	Q5VVH5	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	32296183
Intra	MISP	Q8IVT2	MORN3	Homo sapiens	Q6PF18	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amyotrophic Lateral Sclerosis Type 22	Als 22 Amyotrohpic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia Amyotrophic Lateral Sclerosis 22
Prostatic Adenoma	Prostatic Hyperplasia Adenoma - Prostate Adenoma Of Prostate Benign Adenoma Of Prostate Prostate Adenoma Benign Prostatic Hyperplasia
Male Reproductive Organ Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08465	MISP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08466	MISP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22236	Misp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28758	Misp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MISP	VGNC	VGNC:43246
Felis catus	MISP	VGNC	VGNC:63519
Bos taurus	MISP	VGNC	VGNC:31486
Rattus norvegicus	MISP	RGD	RGD:1595680
Mus musculus	MISP	MGD	MGI:1926156
Macaca mulatta	MISP	VGNC	VGNC:74840
Others	MISP	NCBI