PNMA2 - PNMA family member 2 Gene

Also Known as MA2; MM2; RGAG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10687

About PNMA2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,504,701-26,513,872 (from NCBI)

This gene has 8 transcripts (splice variants), 579 orthologues and 13 paralogues. Biased expression in brain (RPKM 63.2), adrenal (RPKM 6.1) and 1 other tissue.

Summary

Predicted to be involved in positive regulation of apoptotic process. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

PNMA2 Products (1)

mRNA	Protein	Name
NM_007257.6	NP_009188.1	paraneoplastic antigen Ma2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNMA2 Protein Structure

PNMA

0
100
200
300
364 a.a.

Protein Preferred Names	Protein Names
paraneoplastic antigen Ma2	40 kDa neuronal protein

PNMA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PNMA2	Q9UL42	RTP5	Homo sapiens	Q14D33	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	PRPF31	Homo sapiens	Q8WWY3	Y2H Array	25416956
Intra	PNMA2	Q9UL42	PRPF31	Homo sapiens	Q8WWY3	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	LRR1	Homo sapiens	Q96L50	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	LRR1	Homo sapiens	Q96L50	Y2H Array	25416956
Intra	PNMA2	Q9UL42	RPL9	Homo sapiens	P32969	Y2H Array	25416956
Intra	PNMA2	Q9UL42	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	RNF8	Homo sapiens	O76064	Y2H Array	25416956
Intra	PNMA2	Q9UL42	RNF8	Homo sapiens	O76064	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	TOP3B	Homo sapiens	O95985	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	PPIG	Homo sapiens	Q13427	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	MORF4L2	Homo sapiens	Q15014	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	MORF4L2	Homo sapiens	Q15014	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	PNMA2	Q9UL42	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	ZNF587	Homo sapiens	Q96SQ5	Y2H Array	25416956
Intra	PNMA2	Q9UL42	CBX8	Homo sapiens	Q9HC52	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	CBX8	Homo sapiens	Q9HC52	Y2H Array	25416956
Intra	PNMA2	Q9UL42	FAM161A	Homo sapiens	Q3B820	Anti Tag CoIP	33961781
Intra	PNMA2	Q9UL42	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	PNMA2	Q9UL42	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	PNMA2	Q9UL42	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	ZNF417	Homo sapiens	Q8TAU3	Y2H	21516116
Intra	PNMA2	Q9UL42	ENKD1	Homo sapiens	Q9H0I2	Y2H Prey Pooling	25416956
Intra	PNMA2	Q9UL42	ENKD1	Homo sapiens	Q9H0I2	Anti Tag CoIP	33961781
Intra	PNMA2	Q9UL42	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	25416956
Intra	PNMA2	Q9UL42	TTLL10	Homo sapiens	Q6ZVT0	Validated Y2H	25416956
Intra	PNMA2	Q9UL42	TTLL10	Homo sapiens	Q6ZVT0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Limbic Encephalitis
Autoimmune Epilepsy
Anterograde Amnesia	Amnesia, Anterograde
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Oculomotor Nerve Paralysis	Iii Nerve Palsy Iiird Nerve Paralysis Third Cranial Nerve Paralysis
Neurosarcoidosis	Cerebral Sarcoidosis
Kleine-Levin Hibernation Syndrome	Kleine-Levin Syndrome Familial Kleine-Levin Syndrome Kleine Levin Syndrome Familial Hibernation Syndrome Recurrent Hypersomnolence Hypersomnia-Bulimia Syndrome
Retinitis Pigmentosa 34	RP34
Recurrent Hypersomnia	Primary Recurrent Hypersomnia Hypersomnia Recurrent Disorders Of Excessive Somnolence Hypersomnia, Recurrent
Acute Disseminated Encephalomyelitis	Acute Disseminated Encephalitis Adem Ade Encephalomyelitis Acute Disseminated Encephalomyelitis, Acute Disseminated Adem - [Acute Disseminated Encephalomyelitis]
Postinfectious Encephalitis	Postinfective Encephalitis Secondary Encephalitis
La Crosse Encephalitis	California Encephalitis California Virus Encephalitis Neuroinvasive California Encephalitis Virus Infection Californian Encephalitis Encephalitis, California California Meningoencephalitis California Encephalitis Virus Infection California Encephalitis Virus Infection Neuroinvasive Disease California Meningoencephalitis Virus Disease California Serogroup Virus Neuroinvasive Disease California Viral Encephalitis Ce - [California Encephalitis] Lac - [La Crosse Encephalitis]
Whipple Disease	Intestinal Lipodystrophy Whipple'S Disease Intestinal Lipophagic Granulomatosis Secondary Non-Tropical Sprue Tropheryma Whippelii Infection Whipples Disease
Stiff-Person Syndrome	SPS Stiff-Man Syndrome Stiff Man Syndrome Stiff Person Syndrome Moersch-Woltman Syndrome Sms Stiff-Trunk Syndrome Morsch Woltman Syndrome Stiff Person Syndrome And Related Disorders Stiff Person Spectrum Disorder Classic Stiff Person Syndrome Classic Sps Focal Stiff Limb Syndrome Focal Stiff-Person Syndrome Stiff Leg Syndrome Progressive Encephalomyelitis With Rigidity
Small Intestine Neuroendocrine Neoplasm	Small Intestine Neuroendocrine Tumor Neuroendocrine Tumor Of The Small Intestine Net Of The Small Intestine Neuroendocrine Neoplasm Of The Small Intestine Neuroendocrine Tumor Of Small Bowel Small Intestinal Neuroendocrine Neoplasm
Akinetic Mutism	Coma Vigilans
Lingual-Facial-Buccal Dyskinesia	Orofacial Dyskinesia Oro-Facial Dyskinesia Dyskinesias
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Lateral Medullary Syndrome	Posterior Inferior Cerebellar Artery Syndrome Wallenberg Syndrome Vertebral Artery Syndrome Wallenberg'S Syndrome Pica Syndrome
Autoimmune Disease Of Peripheral Nervous System
Miller Fisher Syndrome	Cranial Variant Of Gbs Fisher'S Syndrome Miller-Fisher Variant Of Guillain-Barre Syndrome Miller-Fisher Syndrome Cranial Variant Of Guillain-Barré Syndrome Cranial Variant Of Guillain-Barre Syndrome Fisher Syndrome
Third Cranial Nerve Disease	Disorder Of Oculomotor Nerve Oculomotor Nerve Disorder Oculomotor Nerve Paralysis Third Cranial Nerve Disorder
Mutism
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Thymus Gland Disease	Disease Of Thymus Gland
Gummatous Syphilis
Spastic Hemiplegia	Spastic Hemiplegic Cerebral Palsy Hemiplegic Cerebral Palsy Congenital Hemiplegia Hemiplegic Infantile Cerebral Palsy Cerebral Palsy Spastic Hemiplegic Spastic Hemiplegia Cerebral Palsy Hemiplegia, Spastic
Small Intestine Benign Neoplasm	Neoplasm Of Small Intestine Small Intestinal Neoplasm Neoplasm Of The Small Intestine Small Bowel Cancer Small Intestine Cancer Malignant Neoplasm Of Small Intestine, Unspecified Malignant Tumour Of Small Bowel Malignant Tumour Of Small Intestine Primary Malignant Neoplasm Of Meckel Diverticulum
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer
Internuclear Ophthalmoplegia	Ophthalmoplegia Internuclearis Bielschowsky-Lutz-Cogan Syndrome Ino - [Internuclear Ophthalmoplegia] Lhermitte Syndrome Mlf - [Medial Longitudinal Fasciculus] Syndrome Internuclear Paralysis
Meningovascular Neurosyphilis
Neuromuscular Junction Disease	Neuromuscular Junction Diseases
Invasive Malignant Thymoma	Infiltrating Thymoma Thymoma Malignant Invasive Invasive Thymoma And Thymic Carcinoma
Fallopian Tube Serous Adenocarcinoma
Choreatic Disease	Chorea Hereditary Chorea
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10783	PNMA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PNMA2	VGNC	VGNC:44747
Bos taurus	PNMA2	VGNC	VGNC:33084
Mus musculus	PNMA2	MGD	MGI:2444129
Macaca mulatta	PNMA2	VGNC	VGNC:84102
Rattus norvegicus	PNMA2	RGD	RGD:1307266
Felis catus	PNMA2	VGNC	VGNC:79973
Others	PNMA2	NCBI