TOP3B - DNA topoisomerase III beta Gene

Also Known as TOP3B1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8940

About TOP3B

Cytogenetic location: 22q11.22 Genomic coordinates (GRCh38): 22:21,957,025-21,982,787 (from NCBI)

This gene has 17 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 4.6), lymph node (RPKM 3.7) and 25 other tissues.

Summary

This gene encodes a DNA Topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast Cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

TOP3B Products (9)

mRNA	Protein	Name
NM_001282112.2	NP_001269041.1	DNA topoisomerase 3-beta-1 isoform 1
NM_001282113.2	NP_001269042.1	DNA topoisomerase 3-beta-1 isoform 1
NM_001349845.2	NP_001336774.1	DNA topoisomerase 3-beta-1 isoform 1
NM_001349847.2	NP_001336776.1	DNA topoisomerase 3-beta-1 isoform 1
NM_001349848.2	NP_001336777.1	DNA topoisomerase 3-beta-1 isoform 2
NM_001349850.2	NP_001336779.1	DNA topoisomerase 3-beta-1 isoform 2
NM_001349851.2	NP_001336780.1	DNA topoisomerase 3-beta-1 isoform 3
NM_001349852.2	NP_001336781.1	DNA topoisomerase 3-beta-1 isoform 3
NM_003935.5	NP_003926.1	DNA topoisomerase 3-beta-1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA topoisomerase activity	IDA IDA: Inferred from direct assay	23912945	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DNA topoisomerase III-beta-TDRD3 complex	IPI IPI: Inferred from physical interaction	28176834	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23912945	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOP3B Protein Structure

Toprim

Topoisom_bac

0
200
400
600
800
862 a.a.

Protein Preferred Names	Protein Names
DNA topoisomerase 3-beta-1	DNA topoisomerase III beta-1

TOP3B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TOP3B	O95985	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	TOP3B	O95985	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	25416956
Intra	TOP3B	O95985	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	TOP3B	O95985	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	TOP3B	O95985	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	25416956
Intra	TOP3B	O95985	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	25416956
Intra	TOP3B	O95985	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
Intra	TOP3B	O95985	ZNF250	Homo sapiens	P15622-3	Y2H Array	32296183
Intra	TOP3B	O95985	ZNF250	Homo sapiens	P15622-3	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	TDRD3	Homo sapiens	Q9H7E2-3	X-Ray Diffraction	28176834
Intra	TOP3B	O95985	TDRD3	Homo sapiens	Q9H7E2-3	Pull Down	28176834
Intra	TOP3B	O95985	TDRD3	Homo sapiens	Q9H7E2-3	GMS	28176834
Intra	TOP3B	O95985	TDRD3	Homo sapiens	Q9H7E2-3	Footprinting	28176834
Intra	TOP3B	O95985	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	TOP3B	O95985	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	TOP3B	O95985	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	FASTK	Homo sapiens	Q14296	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	FASTK	Homo sapiens	Q14296	Validated Y2H	32296183
Intra	TOP3B	O95985	FASTK	Homo sapiens	Q14296	Y2H Array	32296183
Intra	TOP3B	O95985	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	TOP3B	O95985	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	TOP3B	O95985	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	TOP3B	O95985	PNMA2	Homo sapiens	Q9UL42	Validated Y2H	25416956
Intra	TOP3B	O95985	PNMA2	Homo sapiens	Q9UL42	Y2H Array	25416956
Intra	TOP3B	O95985	AXIN2	Homo sapiens	Q9Y2T1	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	AXIN2	Homo sapiens	Q9Y2T1	Validated Y2H	32296183
Intra	TOP3B	O95985	AXIN2	Homo sapiens	Q9Y2T1	Y2H Array	32296183
Intra	TOP3B	O95985	SPRED2	Homo sapiens	Q7Z698	Validated Y2H	25416956
Intra	TOP3B	O95985	SPRED2	Homo sapiens	Q7Z698	Y2H Array	25416956
Intra	TOP3B	O95985	CIAO1	Homo sapiens	O76071	Y2H Prey Pooling	32296183
Intra	TOP3B	O95985	CIAO1	Homo sapiens	O76071	Y2H Array	32296183
Intra	TOP3B	O95985	CIAO1	Homo sapiens	O76071	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

TOP3B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810952	Topoisomerase 3 beta1 Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Li-Fraumeni Syndrome 2	LFS2 Li-Fraumeni Syndrome, Type 2 Li-Fraumeni Syndrome
Chromosome 22q11.2 Duplication Syndrome	Chromosome 22q11.2 Microduplication Syndrome 22q11.2 Microduplication Syndrome 22q11.2 Duplication Syndrome Duplication 22q11.2 Trisomy 22q11.2 22q11.2 Duplication Dup(22)(Q11)
Kidney Rhabdoid Cancer	Rhabdoid Tumor Of The Kidney Kidney Rhabdoid Tumor Renal Rhabdoid Tumor
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Epilepsy, Myoclonic Juvenile	Juvenile Myoclonic Epilepsy Janz Syndrome Jme Myoclonic Epilepsy, Juvenile, Susceptibility To, 1 EJM Myoclonic Epilepsy, Juvenile Petit Mal, Impulsive Myoclonic Epilepsy, Juvenile 1 Myoclonic Epilepsy, Juvenile, 1 Adolescent Myoclonic Epilepsy Juvenile Myoclonus Epilepsy Juvenile Myoclonic Epilepsy 1 EJM1 Petit Mal Impulsive Susceptibility To Juvenile Myoclonic Epilepsy 1 Myoclonic Epilepsy Juvenile Epilepsy, Myoclonic, Juvenile Myoclonic Epilepsy Of Janz Jme - [Juvenile Myoclonic Epilepsy]
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14899	TOP3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176762	TOP3B-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TOP3B	VGNC	VGNC:66451
Canis familiaris	TOP3B	VGNC	VGNC:49634
Rattus norvegicus	TOP3B	RGD	RGD:1309468
Macaca mulatta	TOP3B	VGNC	VGNC:78623
Mus musculus	TOP3B	MGD	MGI:1333803
Bos taurus	TOP3B	VGNC	VGNC:106991
Others	TOP3B	NCBI