1. Gene
  2. SPRED2 - sprouty related EVH1 domain containing 2 Gene

SPRED2 - sprouty related EVH1 domain containing 2 Gene

Homo sapiens

Also known as NS14; Spred-2

Gene ID: 200734 | Gene type: protein coding

About SPRED2

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:65,307,175-65,432,599 (from NCBI)

This gene has 8 transcripts (splice variants), 278 orthologues, 5 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 9.3), fat (RPKM 9.2) and 25 other tissues.

Summary

SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

SPRED2 Products(2)

mRNA Protein Name
NM_001128210.2 NP_001121682.1 sprouty-related, EVH1 domain-containing protein 2 isoform b
NM_181784.3 NP_861449.2 sprouty-related, EVH1 domain-containing protein 2 isoform a

SPRED2 Protein Structure

WH1

WH1: WH1 domain (14 - 118)

Sprouty

Sprouty: Sprouty protein (Spry) (306 - 411)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
Protein Preferred Names Protein Names

sprouty-related, EVH1 domain-containing protein 2

sprouty protein with EVH-1 domain 2, related sequence

Related Diseases

Diseases Alias
Noonan Syndrome 14

NS14

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Pseudo-Turner Syndrome

Noonan Syndrome

Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPRED2 VGNC VGNC:106225
Canis familiaris SPRED2 VGNC VGNC:46763
Bos taurus SPRED2 VGNC VGNC:58416
Mus musculus SPRED2 MGD MGI:2150019
Rattus norvegicus SPRED2 RGD RGD:1309304
Felis catus SPRED2 VGNC VGNC:65647