TOP3B-IN-1
TOP3B-IN-1 (NSC-260610) is a Topoisomerase IIIβ (TOP3B) inhibitor. TOP3B-IN-1 fails to induce the formation of TOP3B cleavage complexes (TOP3Bccs) with both DNA and RNA, and destabilizes TOP3Bccs. TOP3B-IN-1 can be used as a control compound for the development of inhibitors targeting TOP3B.
For research use only. We do not sell to patients.
- CAS No.: 67047-17-0
- Formula: C34H34N4O2
- Molecular Weight:530.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| P388 | IC50 |
0.24 μM
Compound: 9a
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Growth inhibition of mouse P388 cells by in vitro assay
Growth inhibition of mouse P388 cells by in vitro assay
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[PMID: 722754] |
Chemical Information
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CAS No. 67047-17-0
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Molecular Weight 530.66
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Formula C34H34N4O2
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SMILES
COC1=CC2=NC3=C(C=CC=C3)C(NCCCCCCNC4=C5C=CC(OC)=CC5=NC6=C4C=CC=C6)=C2C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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