RPL9 - ribosomal protein L9 Gene

Also Known as L9; NPC-A-16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6133

About RPL9

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,454,124-39,458,922 (from NCBI)

This gene has 15 transcripts (splice variants) and 172 orthologues. Ubiquitous expression in ovary (RPKM 1269.0), bone marrow (RPKM 646.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RPL9 Products (2)

mRNA	Protein	Name
NM_000661.5	NP_000652.2	60S ribosomal protein L9
NM_001024921.4	NP_001020092.1	60S ribosomal protein L9

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL9 Protein Structure

Ribosomal_L6

0
100
192 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L9	large ribosomal subunit protein uL6

RPL9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPL9	P32969	BICDL2	Homo sapiens	A1A5D9	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	BICDL2	Homo sapiens	A1A5D9	Y2H Array	32296183
Intra	RPL9	P32969	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	RPL9	P32969	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	RPL9	P32969	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	RPL9	P32969	CCDC184	Homo sapiens	Q52MB2	Validated Y2H	32296183
Intra	RPL9	P32969	CCDC184	Homo sapiens	Q52MB2	Y2H Array	32296183
Intra	RPL9	P32969	CCDC184	Homo sapiens	Q52MB2	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	SREK1IP1	Homo sapiens	Q8N9Q2	Y2H Array	32296183
Intra	RPL9	P32969	SREK1IP1	Homo sapiens	Q8N9Q2	Validated Y2H	32296183
Intra	RPL9	P32969	SREK1IP1	Homo sapiens	Q8N9Q2	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	RPL9	P32969	CTNNA3	Homo sapiens	Q9UI47-2	Validated Y2H	32296183
Intra	RPL9	P32969	CTTN	Homo sapiens	Q14247-3	Y2H Array	32296183
Intra	RPL9	P32969	CTTN	Homo sapiens	Q14247-3	Validated Y2H	32296183
Intra	RPL9	P32969	CTTN	Homo sapiens	Q14247-3	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	RPL9	P32969	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	RPL9	P32969	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
Intra	RPL9	P32969	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
Intra	RPL9	P32969	PNMA2	Homo sapiens	Q9UL42	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	PNMA2	Homo sapiens	Q9UL42	Validated Y2H	25416956
Intra	RPL9	P32969	PNMA2	Homo sapiens	Q9UL42	Validated Y2H	32296183
Intra	RPL9	P32969	PNMA2	Homo sapiens	Q9UL42	Y2H Array	32296183
Intra	RPL9	P32969	PNMA2	Homo sapiens	Q9UL42	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	VCP	Homo sapiens	P55072	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	VCP	Homo sapiens	P55072	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	VCP	Homo sapiens	P55072	Validated Y2H	32296183
Intra	RPL9	P32969	VCP	Homo sapiens	P55072	Validated Y2H	25416956
Intra	RPL9	P32969	VCP	Homo sapiens	P55072	Y2H Array	32296183
Intra	RPL9	P32969	VCP	Homo sapiens	P55072	Y2H Array	25416956
Intra	RPL9	P32969	SNRPF	Homo sapiens	P62306	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	SNRPF	Homo sapiens	P62306	Y2H Array	32296183
Intra	RPL9	P32969	SNRPF	Homo sapiens	P62306	Validated Y2H	32296183
Intra	RPL9	P32969	SRSF3	Homo sapiens	P84103	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	SRSF3	Homo sapiens	P84103	Y2H Array	32296183
Intra	RPL9	P32969	SRSF3	Homo sapiens	P84103	Validated Y2H	32296183
Intra	RPL9	P32969	PPP1R27	Homo sapiens	Q86WC6	Y2H Array	32296183
Intra	RPL9	P32969	PPP1R27	Homo sapiens	Q86WC6	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	PPP1R27	Homo sapiens	Q86WC6	Validated Y2H	32296183
Intra	RPL9	P32969	DRAP1	Homo sapiens	Q14919	Validated Y2H	32296183
Intra	RPL9	P32969	DRAP1	Homo sapiens	Q14919	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	DRAP1	Homo sapiens	Q14919	Y2H Array	32296183
Intra	RPL9	P32969	KXD1	Homo sapiens	Q9BQD3	Validated Y2H	25416956
Intra	RPL9	P32969	ZBTB7B	Homo sapiens	O15156	Validated Y2H	25416956
Intra	RPL9	P32969	TIFA	Homo sapiens	Q96CG3	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	TIFA	Homo sapiens	Q96CG3	Validated Y2H	25416956
Intra	RPL9	P32969	TIFA	Homo sapiens	Q96CG3	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	TIFA	Homo sapiens	Q96CG3	Validated Y2H	32296183
Intra	RPL9	P32969	TIFA	Homo sapiens	Q96CG3	Y2H Array	32296183
Intra	RPL9	P32969	TRIM37	Homo sapiens	O94972	Validated Y2H	25416956
Intra	RPL9	P32969	TRIM37	Homo sapiens	O94972	Y2H Array	25416956
Intra	RPL9	P32969	TRIM37	Homo sapiens	O94972	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	RPL9	P32969	DHPS	Homo sapiens	P49366	Y2H Array	32296183
Intra	RPL9	P32969	DHPS	Homo sapiens	P49366	Anti Tag CoIP	33961781
Intra	RPL9	P32969	DHPS	Homo sapiens	P49366	Anti Tag CoIP	28514442
Intra	RPL9	P32969	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	DHPS	Homo sapiens	P49366	Validated Y2H	32296183
Intra	RPL9	P32969	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	RPL9	P32969	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	RPL9	P32969	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	RPL9	P32969	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	RPL9	P32969	CEP76	Homo sapiens	Q8TAP6	Anti Tag CoIP	33961781
Intra	RPL9	P32969	CEP76	Homo sapiens	Q8TAP6	Anti Tag CoIP	28514442
Intra	RPL9	P32969	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	RPL9	P32969	STAC3	Homo sapiens	Q96MF2	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	STAC3	Homo sapiens	Q96MF2	Y2H Array	32296183
Intra	RPL9	P32969	STAC3	Homo sapiens	Q96MF2	Validated Y2H	32296183
Intra	RPL9	P32969	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	TNFAIP8L1	Homo sapiens	Q8WVP5	Validated Y2H	32296183
Intra	RPL9	P32969	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Array	32296183
Intra	RPL9	P32969	RALY	Homo sapiens	Q53GL6	Y2H Prey Pooling	32296183
Intra	RPL9	P32969	RALY	Homo sapiens	Q53GL6	Validated Y2H	32296183
Intra	RPL9	P32969	RALY	Homo sapiens	Q53GL6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811235	RPL9 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia 6	DBA6 Aase-Smith Syndrome Ii Aase Syndrome Aase Smith Syndrome 2 Rpl5-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 6 Diamond-Blackfan Anemia 1
Diamond-Blackfan Anemia 2	DBA2 Anemia, Diamond-Blackfan, 2 Anemia Diamond-Blackfan 2
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12206	RPL9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22309	Rpl9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28831	Rpl9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RPL9	RGD	RGD:62049
Mus musculus	RPL9	MGD	MGI:1298373
Felis catus	RPL9	VGNC	VGNC:79993
Macaca mulatta	RPL9	VGNC	VGNC:107196
Canis familiaris	RPL9	VGNC	VGNC:53205
Others	RPL9	NCBI