SRSF3 - serine and arginine rich splicing factor 3 Gene

Homo sapiens

Also known as SFRS3; SRp20

Gene ID: 6428 | Gene type: protein coding

About SRSF3

Cytogenetic location: 6p21.31-p21.2 Genomic coordinates (GRCh38): 6:36,594,362-36,605,600 (from NCBI)

This gene has 8 transcripts (splice variants), 319 orthologues, 8 paralogues and is associated with 50 phenotypes. Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

SRSF3 Products(1)

mRNA	Protein	Name
NM_003017.5	NP_003008.1	serine/arginine-rich splicing factor 3

SRSF3 Protein Structure

RRM_1

0
100
164 a.a.

Protein Preferred Names

Protein Names

serine/arginine-rich splicing factor 3

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Intellectual Developmental Disorder, Autosomal Dominant 4

MRD4	Autosomal Dominant Non-Syndromic Intellectual Disability 4
Mental Retardation, Autosomal Dominant 4	Autosomal Dominant Intellectual Developmental Disorder 4

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13794	SRSF3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRSF3	VGNC	VGNC:77820
Rattus norvegicus	SRSF3	RGD	RGD:1309233
Canis familiaris	SRSF3	VGNC	VGNC:46819
Bos taurus	SRSF3	VGNC	VGNC:35301
Mus musculus	SRSF3	MGD	MGI:98285

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