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PCBP2 - poly(rC) binding protein 2 Gene

Also Known as HNRPE2; HNRNPE2; hnRNP-E2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5094

About PCBP2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,452,102-53,481,162 (from NCBI)

This gene has 26 transcripts (splice variants), 280 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 155.8), thyroid (RPKM 127.6) and 25 other tissues.

Summary

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]

PCBP2 Products (7)

mRNA	Protein	Name
NM_001098620.3	NP_001092090.1	poly(rC)-binding protein 2 isoform c
NM_001128911.2	NP_001122383.1	poly(rC)-binding protein 2 isoform d
NM_001128912.2	NP_001122384.1	poly(rC)-binding protein 2 isoform e
NM_001128913.2	NP_001122385.1	poly(rC)-binding protein 2 isoform f
NM_001128914.2	NP_001122386.1	poly(rC)-binding protein 2 isoform g
NM_005016.6	NP_005007.2	poly(rC)-binding protein 2 isoform a
NM_031989.5	NP_114366.1	poly(rC)-binding protein 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	7607214	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19881509	GOA
enables lncRNA binding	IDA IDA: Inferred from direct assay	31361039	GOA
enables promoter-enhancer loop anchoring activity	IMP IMP: Inferred from mutant phenotype	31361039	GOA
enables protein binding	IDA IDA: Inferred from direct assay	35322803	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19881509	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	12414943	GOA
involved in chromatin looping	IMP IMP: Inferred from mutant phenotype	31361039	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	35322803	GOA
involved in negative regulation of defense response to virus	IMP IMP: Inferred from mutant phenotype	19881509	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19881509	GOA
involved in viral RNA genome replication	IDA IDA: Inferred from direct assay	12414943	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19029303	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	31361039	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCBP2 Protein Structure

KH_1

0
100
200
300
365 a.a.

Protein Preferred Names	Protein Names
poly(rC)-binding protein 2	alpha-CP2

PCBP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PCBP2	Q15366	SRSF3	Homo sapiens	P84103	Anti Bait CoIP	17183366
Intra	PCBP2	Q15366	SRSF3	Homo sapiens	P84103	Y2H	17183366
Intra	PCBP2	Q15366	SNRPA	Homo sapiens	P09012	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PCBP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81798	PCBP2 Antibody (YA1543)	WB, IP	Mouse, Rat
HY-P81798A	PCBP2 Antibody (YA1543)(PBS only)	WB, IP	Mouse, Rat

Related Diseases

Diseases	Alias
Rabies	Lyssa Hydrophobia St Hubert Disease
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Deficiency Anemia	Anemia Deficiency Anemias Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10116	PCBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20075	Pcbp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26578	Pcbp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PCBP2	VGNC	VGNC:49069
Rattus norvegicus	PCBP2	RGD	RGD:1309626
Mus musculus	PCBP2	MGD	MGI:108202
Others	PCBP2	NCBI