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TIFA - TRAF interacting protein with forkhead associated domain Gene

Also Known as T2BP; T6BP; TIFAA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 92610

About TIFA

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:112,274,537-112,285,904 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 11.2), thyroid (RPKM 11.0) and 25 other tissues.

Summary

This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to Bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and Other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]

TIFA Products (1)

mRNA	Protein	Name
NM_052864.3	NP_443096.1	TRAF-interacting protein with FHA domain-containing protein A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11798190	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	26068852	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	26068852	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	26068852	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	22566686	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22566686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIFA Protein Structure

FHA

0
100
184 a.a.

Protein Preferred Names	Protein Names
TRAF-interacting protein with FHA domain-containing protein A	TRAF-interacting protein with a forkhead-associated domain

TIFA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TIFA	Q96CG3	TNFAIP8	Homo sapiens	O95379	Y2H Prey Pooling	25416956
Intra	TIFA	Q96CG3	TUT4	Homo sapiens	Q5TAX3-1	Anti Tag CoIP	16643855
Intra	TIFA	Q96CG3	TIFAB	Homo sapiens	Q6ZNK6	Anti Tag CoIP	15047173
Intra	TIFA	Q96CG3	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	TIFA	Q96CG3	TXN2	Homo sapiens	Q99757	Validated Y2H	25416956
Intra	TIFA	Q96CG3	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	TIFA	Q96CG3	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	TIFA	Q96CG3	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	11798190
Intra	TIFA	Q96CG3	RPL9	Homo sapiens	P32969	Y2H Array	25416956
Intra	TIFA	Q96CG3	TRAF6	Homo sapiens	Q9Y4K3	BFG-2H	27107012
Intra	TIFA	Q96CG3	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	26068852
Intra	TIFA	Q96CG3	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	25416956
Intra	TIFA	Q96CG3	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	TIFA	Q96CG3	NXF1	Homo sapiens	Q9UBU9	Y2H Array	25416956
Intra	TIFA	Q96CG3	NXF1	Homo sapiens	Q9UBU9	Y2H Prey Pooling	25416956
Cross	TIFA	Q96CG3	Traf6	Mus musculus	P70196	Anti Tag CoIP	15047173
Intra	TIFA	Q96CG3	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	TIFA	Q96CG3	SDCBP	Homo sapiens	O00560	BFG-2H	27107012
Intra	TIFA	Q96CG3	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	TIFA	Q96CG3	DVL2	Homo sapiens	O14641	BFG-2H	27107012
Intra	TIFA	Q96CG3	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	TIFA	Q96CG3	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
Intra	TIFA	Q96CG3	SDCBP2	Homo sapiens	Q9H190	BFG-2H	27107012
Intra	TIFA	Q96CG3	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	25416956
Intra	TIFA	Q96CG3	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956
Intra	TIFA	Q96CG3	ARHGEF39	Homo sapiens	Q8N4T4	Y2H Array	31515488
Intra	TIFA	Q96CG3	ARHGEF39	Homo sapiens	Q8N4T4	Validated Y2H	25416956
Intra	TIFA	Q96CG3	ARHGEF39	Homo sapiens	Q8N4T4	Y2H Prey Pooling	25416956
Intra	TIFA	Q96CG3	ARHGEF39	Homo sapiens	Q8N4T4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chronic Gonococcal Salpingitis	Gonococcal Salpingitis
Acute Salpingitis
Chronic Salpingitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06736	IL22 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14521	TIFA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18262	Tifa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24741	Tifa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TIFA	VGNC	VGNC:107474
Rattus norvegicus	TIFA	RGD	RGD:1359151
Mus musculus	TIFA	MGD	MGI:2182965
Canis familiaris	TIFA	VGNC	VGNC:54373
Bos taurus	TIFA	VGNC	VGNC:35862
Macaca mulatta	TIFA	VGNC	VGNC:79179
Others	TIFA	NCBI