TIFAB - TIFA inhibitor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 497189

About TIFAB

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,444,226-135,452,351 (from NCBI)

This gene has 1 transcript (splice variant), 73 orthologues and 1 paralogue. Biased expression in lymph node (RPKM 4.5), appendix (RPKM 3.4) and 12 other tissues.

Summary

TIFAB associates with TIFA (MIM 609028) and inhibits TIFA-mediated activation of NF-kappa-B (NFKB1; MIM 164011) (Matsumura et al., 2004 [PubMed 15047173]).[supplied by OMIM, Mar 2009]

TIFAB Products (1)

mRNA Protein Name
NM_001099221.2 NP_001092691.1 TRAF-interacting protein with FHA domain-containing protein B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15047173 GOA
Biological Process GO Annotation Evidence References Source
involved in auditory behavior IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in cochlea development IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in craniofacial suture morphogenesis IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in genitalia development IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in genitalia morphogenesis IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in hard palate morphogenesis IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in inner ear development IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in learned vocalization behavior IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in mastication IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in negative regulation of relaxation of muscle IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in negative regulation of saliva secretion IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in neuromuscular process controlling balance IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in peristalsis IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in regulation of muscle organ development IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in thorax and anterior abdomen determination IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in trigeminal nerve development IGI
IGI: Inferred from genetic interaction
23419067 GOA
involved in vestibulocochlear nerve formation IGI
IGI: Inferred from genetic interaction
23419067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIFAB Protein Structure

FHA

FHA: FHA domain (37 - 107)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

TRAF-interacting protein with FHA domain-containing protein B

  • TIFA-like protein

TIFAB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TIFAB Q6ZNK6 USP15 Homo sapiens Q9Y4E8
Anti Tag CoIP
32101751
Intra
TIFAB Q6ZNK6 USP15 Homo sapiens Q9Y4E8
TAP
32101751
Intra
TIFAB Q6ZNK6 TIFA Homo sapiens Q96CG3
TAP
32101751
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS14522 TIFAB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TIFAB VGNC VGNC:47367
Mus musculus TIFAB MGD MGI:2385852
Felis catus TIFAB VGNC VGNC:102344
Rattus norvegicus TIFAB RGD RGD:1311681
Macaca mulatta TIFAB VGNC VGNC:79944
Bos taurus TIFAB VGNC VGNC:52889
Others TIFAB NCBI