USP15 - ubiquitin specific peptidase 15 Gene

Homo sapiens

Also known as UNPH4; UNPH-2

Gene ID: 9958 | Gene type: protein coding

About USP15

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:62,260,404-62,416,389 (from NCBI)

This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues.

Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

USP15 Products(11)

mRNA	Protein	Name
NM_001252078.2	NP_001239007.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 1
NM_001252079.2	NP_001239008.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 3
NM_001351159.2	NP_001338088.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 4
NM_001351160.2	NP_001338089.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 5
NM_001351161.2	NP_001338090.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 6
NM_001351162.2	NP_001338091.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 7
NM_001351163.2	NP_001338092.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351164.2	NP_001338093.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351165.2	NP_001338094.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351166.2	NP_001338095.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_006313.3	NP_006304.1	ubiquitin carboxyl-terminal hydrolase 15 isoform 2

USP15 Protein Structure

DUSP

Ubiquitin_3

UCH

0
200
400
600
800
981 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 15

deubiquitinating enzyme 15

Related Diseases

Diseases

Alias

Microphthalmia, Isolated 1

Isolated Microphthalmia 1	MCOP1
Mcop	Anophthalmia, Clinical, Isolated
Microphthalmos, Autosomal Recessive

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148046	USP15-IN-1	Inhibitor	99.42%	Unkown
HY-RS15526	USP15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP15	VGNC	VGNC:66869
Bos taurus	USP15	VGNC	VGNC:36713
Macaca mulatta	USP15	VGNC	VGNC:78737
Mus musculus	USP15	MGD	MGI:101857
Rattus norvegicus	USP15	RGD	RGD:628795
Canis familiaris	USP15	VGNC	VGNC:48180
Others	USP15	NCBI

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