USP15 - ubiquitin specific peptidase 15 Gene

Also Known as UNPH4; UNPH-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9958

About USP15

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:62,260,404-62,416,389 (from NCBI)

This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues.

Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating Enzymes. USP Enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

USP15 Products (11)

mRNA Protein Name
NM_001252078.2 NP_001239007.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 1
NM_001252079.2 NP_001239008.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 3
NM_001351159.2 NP_001338088.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 4
NM_001351160.2 NP_001338089.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 5
NM_001351161.2 NP_001338090.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 6
NM_001351162.2 NP_001338091.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 7
NM_001351163.2 NP_001338092.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351164.2 NP_001338093.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351165.2 NP_001338094.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_001351166.2 NP_001338095.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 8
NM_006313.3 NP_006304.1 ubiquitin carboxyl-terminal hydrolase 15 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables K48-linked deubiquitinase activity IDA
IDA: Inferred from direct assay
24399297 GOA
enables SMAD binding IPI
IPI: Inferred from physical interaction
21947082 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
16005295 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
21947082 GOA
enables deubiquitinase activity IDA
IDA: Inferred from direct assay
32839293 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22001210 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21209336 GOA
enables transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
22344298 GOA
enables ubiquitin-modified histone reader activity IDA
IDA: Inferred from direct assay
24526689 GOA
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
21947082 GOA
involved in monoubiquitinated protein deubiquitination IDA
IDA: Inferred from direct assay
21947082 GOA
involved in negative regulation of antifungal innate immune response IDA
IDA: Inferred from direct assay
33093067 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22344298 GOA
involved in positive regulation of RIG-I signaling pathway IDA
IDA: Inferred from direct assay
24399297 GOA
involved in protein K27-linked deubiquitination IDA
IDA: Inferred from direct assay
33093067 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
16005295 GOA
involved in transcription elongation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
24526689 GOA
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
21947082 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21947082 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21947082 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP15 Protein Structure

DUSP

DUSP: DUSP domain (27 - 118)

Ubiquitin_3

Ubiquitin_3: Ubiquitin-like domain (136 - 222)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (288 - 930)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 981 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 15

  • deubiquitinating enzyme 15

USP15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP15 Q9Y4E8 SYVN1 Homo sapiens Q86TM6
Anti Bait CoIP
31477895
Intra
USP15 Q9Y4E8 ubiq_human Homo sapiens DIP-24261N
Deubiquitinase Assay
32101751
Intra
USP15 Q9Y4E8 CARD9 Homo sapiens Q9H257
Validated Y2H
25416956
Intra
USP15 Q9Y4E8 USP15 Homo sapiens Q9Y4E8
X-Ray Diffraction
22001210
Intra
USP15 Q9Y4E8 SPDL1 Homo sapiens Q96EA4
Validated Y2H
25416956
Intra
USP15 Q9Y4E8 USP15 Homo sapiens Q9Y4E8
GMS
22001210
Intra
USP15 Q9Y4E8 USP15 Homo sapiens Q9Y4E8
SAXS
22001210
Intra
USP15 Q9Y4E8 SPDL1 Homo sapiens Q96EA4
Y2H Array
25416956
Intra
USP15 Q9Y4E8 SPDL1 Homo sapiens Q96EA4
Anti Tag CoIP
33961781
Intra
USP15 Q9Y4E8 CARD9 Homo sapiens Q9H257
Y2H Array
31515488
Intra
USP15 Q9Y4E8 TIFAB Homo sapiens Q6ZNK6
Deubiquitinase Assay
32101751
Intra
USP15 Q9Y4E8 CCDC57 Homo sapiens Q2TAC2
Y2H Prey Pooling
25416956
Intra
USP15 Q9Y4E8 CCDC57 Homo sapiens Q2TAC2
Validated Y2H
25416956
Intra
USP15 Q9Y4E8 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
25416956
Intra
USP15 Q9Y4E8 TRIM21 Homo sapiens P19474
Validated Y2H
25416956
Intra
USP15 Q9Y4E8 TRIM21 Homo sapiens P19474
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microphthalmia, Isolated 1

  • Isolated Microphthalmia 1

  • MCOP1

  • Mcop

  • Anophthalmia, Clinical, Isolated

  • Microphthalmos, Autosomal Recessive
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180171 USP11-IN-1 Inhibitor / Unkown
HY-184273 TH-407a Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP15 VGNC VGNC:66869
Bos taurus USP15 VGNC VGNC:36713
Macaca mulatta USP15 VGNC VGNC:78737
Mus musculus USP15 MGD MGI:101857
Rattus norvegicus USP15 RGD RGD:628795
Canis familiaris USP15 VGNC VGNC:48180
Others USP15 NCBI