2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. USP11-IN-1

USP11-IN-1 (Compound 26) is a selective ubiquitin-specific protease 11 (USP11) inhibitor with an IC50 of 10.9 μM. USP11-IN-1 shows IC50 values of 18.1 and >500 μM for USP4 (SI = 1.7 fold) and USP15 (SI > 100 fold). USP11-IN-1 can be used for the research of USP11-related malignant tumors.

For research use only. We do not sell to patients.

USP11-IN-1

USP11-IN-1 Chemical Structure

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USP11-IN-1 Related Antibodies

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USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15

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Description

USP11-IN-1 (Compound 26) is a selective ubiquitin-specific protease 11 (USP11) inhibitor with an IC50 of 10.9 μM. USP11-IN-1 shows IC50 values of 18.1 and >500 μM for USP4 (SI = 1.7 fold) and USP15 (SI > 100 fold). USP11-IN-1 can be used for the research of USP11-related malignant tumors[1].

IC50 & Target[1]

USP11

10.9 μM (IC50)

USP4

18.1 μM (IC50)

USP15

>500 μM (IC50)

In Vitro

USP11-IN-1 exhibits potent anti-proliferative activity against PEO4 and MDA-MB-231 cells with IC50 values of 0.47 and 6.5μM, while has low cytotoxicity for MRC-5 cells (IC50 > 10 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

USP11-IN-1 Related Antibodies
Molecular Weight

452.95

Formula

C20H25ClN4O4S
SMILES

ClC1=CC=C(CNC(C2=CC(C(CN3CCN(S(C)(=O)=O)CC3)=O)=CN2C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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USP11-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

USP11-IN-1DeubiquitinaseDUBsInhibitorinhibitorinhibit

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USP11-IN-1
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