USP11-IN-1
USP11-IN-1 (Compound 26) is a selective ubiquitin-specific protease 11 (USP11) inhibitor with an IC50 of 10.9 μM. USP11-IN-1 shows IC50 values of 18.1 and >500 μM for USP4 (SI = 1.7 fold) and USP15 (SI > 100 fold). USP11-IN-1 can be used for the research of USP11-related malignant tumors.
For research use only. We do not sell to patients.
- Formula: C20H25ClN4O4S
- Molecular Weight:452.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
USP11 10.9 μM (IC50) |
USP4 18.1 μM (IC50) |
USP15 >500 μM (IC50) |
In Vitro
USP11-IN-1 exhibits potent anti-proliferative activity against PEO4 and MDA-MB-231 cells with IC50 values of 0.47 and 6.5μM, while has low cytotoxicity for MRC-5 cells (IC50 > 10 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 452.95
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Formula C20H25ClN4O4S
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SMILES
ClC1=CC=C(CNC(C2=CC(C(CN3CCN(S(C)(=O)=O)CC3)=O)=CN2C)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
USP11-IN-1 Related Classifications
HY-180171 Related Classifications
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