SPDL1 - spindle apparatus coiled-coil protein 1 Gene

Also Known as CCDC99

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54908

About SPDL1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:169,583,773-169,604,778 (from NCBI)

This gene has 16 transcripts (splice variants), 198 orthologues and 2 paralogues. Broad expression in testis (RPKM 14.1), lymph node (RPKM 4.5) and 21 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein that functions in mitotic spindle formation and chromosome segregation. The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins, and in mitotic checkpoint signaling. [provided by RefSeq, Jul 2016]

SPDL1 Products (6)

mRNA Protein Name
NM_001329639.2 NP_001316568.1 protein Spindly isoform a
NM_001329640.2 NP_001316569.1 protein Spindly isoform a
NM_001329641.2 NP_001316570.1 protein Spindly isoform b
NM_001329642.2 NP_001316571.1 protein Spindly isoform c
NM_001329643.2 NP_001316572.1 protein Spindly isoform d
NM_017785.5 NP_060255.3 protein Spindly isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables kinetochore binding IDA
IDA: Inferred from direct assay
19468067 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19468067 GOA
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
30258100 GOA
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
19468067 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
19468067 GOA
involved in protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
19468067 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19468067 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
19468067 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
19468067 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Spindly

  • arsenite-related gene 1 protein

SPDL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPDL1 Q96EA4 RTP5 Homo sapiens Q14D33
Y2H Prey Pooling
25416956
Intra
SPDL1 Q96EA4 RTP5 Homo sapiens Q14D33
Validated Y2H
25416956
Intra
SPDL1 Q96EA4 RTP5 Homo sapiens Q14D33
Y2H Array
25416956
Intra
SPDL1 Q96EA4 USP15 Homo sapiens Q9Y4E8
Y2H Prey Pooling
25416956
Intra
SPDL1 Q96EA4 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
25416956
Intra
SPDL1 Q96EA4 PPP1R18 Homo sapiens Q6NYC8
Y2H Array
25416956
Intra
SPDL1 Q96EA4 DNAAF4 Homo sapiens Q8WXU2
Y2H Prey Pooling
25416956
Intra
SPDL1 Q96EA4 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Postinflammatory Pulmonary Fibrosis

  • Post-Inflammatory Pulmonary Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13653 SPDL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SPDL1 VGNC VGNC:77992
Felis catus SPDL1 VGNC VGNC:97641
Rattus norvegicus SPDL1 RGD RGD:1306908
Canis familiaris SPDL1 VGNC VGNC:46727
Mus musculus SPDL1 MGD MGI:1917635
Bos taurus SPDL1 VGNC VGNC:50114
Others SPDL1 NCBI