ARHGEF39 - Rho guanine nucleotide exchange factor 39 Gene

Also Known as C9orf100

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84904

About ARHGEF39

This gene has 6 transcripts (splice variants), 202 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 7.7), adrenal (RPKM 3.6) and 25 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARHGEF39 Products (1)

mRNA Protein Name
NM_032818.3 NP_116207.2 rho guanine nucleotide exchange factor 39

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
22327280 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
22327280 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF39 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (27 - 194)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 39

  • Rho guanine nucleotide exchange factor (GEF) 39

ARHGEF39 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARHGEF39 Q8N4T4 TYSND1 Homo sapiens Q2T9J0
Anti Tag CoIP
33961781
Intra
ARHGEF39 Q8N4T4 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
Intra
ARHGEF39 Q8N4T4 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra
ARHGEF39 Q8N4T4 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00959 ARHGEF39 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGEF39 RGD RGD:1310376
Macaca mulatta ARHGEF39 VGNC VGNC:69912
Felis catus ARHGEF39 VGNC VGNC:59907
Canis familiaris ARHGEF39 VGNC VGNC:38088
Mus musculus ARHGEF39 MGD MGI:3036286
Bos taurus ARHGEF39 VGNC VGNC:26117
Others ARHGEF39 NCBI