LRR1 - leucine rich repeat protein 1 Gene

Also Known as LRR-1; PPIL5; 4-1BBLRR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 122769

About LRR1

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,598,940-49,614,672 (from NCBI)

This gene has 5 transcripts (splice variants) and 184 orthologues. Broad expression in testis (RPKM 19.8), bone marrow (RPKM 6.1) and 21 other tissues.

Summary

The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

LRR1 Products (2)

mRNA Protein Name
NM_152329.4 NP_689542.2 leucine-rich repeat protein 1 isoform 1
NM_203467.2 NP_982292.1 leucine-rich repeat protein 1 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRR1 Protein Structure

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (177 - 216)

LRR_1

LRR_1: Leucine Rich Repeat (227 - 248)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat protein 1

  • 4-1BB-mediated signaling molecule

LRR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRR1 Q96L50 PNMA2 Homo sapiens Q9UL42
Y2H Prey Pooling
25416956
Intra
LRR1 Q96L50 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
Intra
LRR1 Q96L50 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
LRR1 Q96L50 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
LRR1 Q96L50 PFKFB4 Homo sapiens Q16877
Y2H Array
32296183
Intra
LRR1 Q96L50 PFKFB4 Homo sapiens Q16877
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anal Canal Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of The Anal Canal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07805 LRR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17372 Lrr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23826 Lrr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRR1 MGD MGI:1916956
Bos taurus LRR1 VGNC VGNC:30997
Macaca mulatta LRR1 VGNC VGNC:99202
Rattus norvegicus LRR1 RGD RGD:1589026
Canis familiaris LRR1 VGNC VGNC:42782
Felis catus LRR1 VGNC VGNC:104485
Others LRR1 NCBI