2. Gene
  3. LRR1 - leucine rich repeat protein 1 Gene

LRR1 - leucine rich repeat protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LRR-1; PPIL5; 4-1BBLRR

Gene ID: 122769 | Gene type: protein coding

About LRR1

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,598,940-49,614,672 (from NCBI)

This gene has 5 transcripts (splice variants) and 184 orthologues. Broad expression in testis (RPKM 19.8), bone marrow (RPKM 6.1) and 21 other tissues.

Summary

The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

LRR1 Products(2)

mRNA Protein Name
NM_152329.4 NP_689542.2 leucine-rich repeat protein 1 isoform 1
NM_203467.2 NP_982292.1 leucine-rich repeat protein 1 isoform 3

LRR1 Protein Structure

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (177 - 216)

LRR_1

LRR_1: Leucine Rich Repeat (227 - 248)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat protein 1

4-1BB-mediated signaling molecule

Related Diseases

Diseases Alias
Anal Canal Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Anal Canal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07805 LRR1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRR1 MGD MGI:1916956
Bos taurus LRR1 VGNC VGNC:30997
Macaca mulatta LRR1 VGNC VGNC:99202
Rattus norvegicus LRR1 RGD RGD:1589026
Canis familiaris LRR1 VGNC VGNC:42782
Felis catus LRR1 VGNC VGNC:104485
Others LRR1 NCBI