MAP1LC3C - microtubule associated protein 1 light chain 3 gamma Gene

Also Known as LC3C; ATG8J

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 440738

Summary

Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
Biased expression in placenta (RPKM 3.9), lung (RPKM 1.9) and 9 other tissues.

MAP1LC3C Products (1)

mRNA Protein Name
NM_001004343.3 NP_001004343.1 microtubule-associated protein 1 light chain 3 gamma

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylethanolamine binding IDA
IDA: Inferred from direct assay
12740394 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19250911 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
25127057 GOA
Biological Process GO Annotation Evidence References Source
involved in aggrephagy IMP
IMP: Inferred from mutant phenotype
28404643 GOA
involved in autophagosome maturation IDA
IDA: Inferred from direct assay
28223137 GOA
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
28223137 GOA
involved in macroautophagy IDA
IDA: Inferred from direct assay
28223137 GOA
involved in protein exit from endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
26431026 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
28223137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP1LC3C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP1LC3C Q9BXW4 RUFY4 Homo sapiens Q6ZNE9
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 RUFY4 Homo sapiens Q6ZNE9
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 NEK9 Homo sapiens Q8TD19
Pull Down
20562859
Intra
MAP1LC3C Q9BXW4 SF3A1 Homo sapiens Q15459
Anti Tag CoIP
20562859
Intra
MAP1LC3C Q9BXW4 TBC1D25 Homo sapiens Q3MII6
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 TBC1D25 Homo sapiens Q3MII6
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 WDFY3 Homo sapiens Q8IZQ1
Anti Tag CoIP
24668264
Intra
MAP1LC3C Q9BXW4 WDFY3 Homo sapiens Q8IZQ1
ITC
24668264
Intra
MAP1LC3C Q9BXW4 WDFY3 Homo sapiens Q8IZQ1
Pull Down
24668264
Intra
MAP1LC3C Q9BXW4 KBTBD6 Homo sapiens Q86V97
Pull Down
25684205
Intra
MAP1LC3C Q9BXW4 ATG13 Homo sapiens O75143
Pull Down
24290141
Intra
MAP1LC3C Q9BXW4 ATG101 Homo sapiens Q9BSB4
Pull Down
24290141
Intra
MAP1LC3C Q9BXW4 ATG101 Homo sapiens Q9BSB4
BioID
34524948
Intra
MAP1LC3C Q9BXW4 SQSTM1 Homo sapiens Q13501
Phage Display
37219487
Intra
MAP1LC3C Q9BXW4 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
24668264
Intra
MAP1LC3C Q9BXW4 SQSTM1 Homo sapiens Q13501
FPS
34799561
Intra
MAP1LC3C Q9BXW4 NIPSNAP2 Homo sapiens O75323
Pull Down
20562859
Intra
MAP1LC3C Q9BXW4 IPO5 Homo sapiens O00410
Pull Down
20562859
Intra
MAP1LC3C Q9BXW4 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 KBTBD7 Homo sapiens Q8WVZ9
Pull Down
25684205
Intra
MAP1LC3C Q9BXW4 KBTBD7 Homo sapiens Q8WVZ9
Pull Down
20562859
Intra
MAP1LC3C Q9BXW4 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 ATG16L1 Homo sapiens Q676U5
Anti Tag CoIP
20562859
Intra
MAP1LC3C Q9BXW4 ACTA2 Homo sapiens P62736
Anti Tag CoIP
33961781
Intra
MAP1LC3C Q9BXW4 ACTA2 Homo sapiens P62736
Anti Tag CoIP
28514442
Intra
MAP1LC3C Q9BXW4 ZNF24 Homo sapiens P17028
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 ZNF24 Homo sapiens P17028
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 ATG4B Homo sapiens Q9Y4P1
Validated Y2H
32296183
Intra
MAP1LC3C Q9BXW4 ATG4B Homo sapiens Q9Y4P1
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 ATG4B Homo sapiens Q9Y4P1
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 NBR1 Homo sapiens Q14596
Pull Down
19250911
Intra
MAP1LC3C Q9BXW4 UBA5 Homo sapiens Q9GZZ9
Pull Down
20562859
Intra
MAP1LC3C Q9BXW4 NCOA7 Homo sapiens Q8NI08
BioID
34524948
Intra
MAP1LC3C Q9BXW4 ULK1 Homo sapiens O75385
Pull Down
24290141
Intra
MAP1LC3C Q9BXW4 ULK1 Homo sapiens O75385
BioID
34524948
Intra
MAP1LC3C Q9BXW4 GMEB2 Homo sapiens Q9UKD1
Validated Y2H
32296183
Intra
MAP1LC3C Q9BXW4 GMEB2 Homo sapiens Q9UKD1
Y2H Array
32296183
Intra
MAP1LC3C Q9BXW4 GMEB2 Homo sapiens Q9UKD1
Y2H Prey Pooling
32296183
Intra
MAP1LC3C Q9BXW4 STK3 Homo sapiens Q13188
Pull Down
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08029 MAP1LC3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08028 MAP1LC3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18108 Map1lc3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21273 Map1lc3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24582 Map1lc3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27792 Map1lc3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown