NEK9 - NIMA related kinase 9 Gene

Also Known as NC; APUG; NERCC; LCCS10; NERCC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91754

About NEK9

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,079,353-75,127,202 (from NCBI)

This gene has 18 transcripts (splice variants), 200 orthologues, 8 paralogues and is associated with 5 phenotypes. Ubiquitous expression in ovary (RPKM 24.4), testis (RPKM 21.8) and 25 other tissues.

Summary

This gene encodes a member of the NimA (never in Mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in Mitosis and, in turn, activates Other family members during Mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016]

NEK9 Products (3)

mRNA	Protein	Name
NM_001329237.2	NP_001316166.1	serine/threonine-protein kinase Nek9 isoform 1
NM_001329238.2	NP_001316167.1	serine/threonine-protein kinase Nek9 isoform 3
NM_033116.6	NP_149107.4	serine/threonine-protein kinase Nek9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	12840024	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	19001501	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12840024	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic cell cycle	IDA IDA: Inferred from direct assay	12840024	GOA
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	19941817	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with centrosome	IDA IDA: Inferred from direct assay	20873783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEK9 Protein Structure

Pkinase

RCC1

0
200
400
600
800
979 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Nek9	NIMA (never in mitosis gene a)- related kinase 9

NEK9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NEK9	Q8TD19	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	NEK9	Q8TD19	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	35271311
Intra	NEK9	Q8TD19	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	25852190
Intra	NEK9	Q8TD19	DYNLL1	Homo sapiens	P63167	Anti Tag CoIP	20562859
Intra	NEK9	Q8TD19	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	NEK9	Q8TD19	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	NEK9	Q8TD19	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	NEK9	Q8TD19	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	NEK9	Q8TD19	PLK1	Homo sapiens	P53350	Y2H	21642957
Intra	NEK9	Q8TD19	PLK1	Homo sapiens	P53350	Pull Down	21642957
Intra	NEK9	Q8TD19	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	NEK9	Q8TD19	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	NEK9	Q8TD19	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

NEK9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81617	NEK9 Antibody (YA1362)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
HY-P81617A	NEK9 Antibody (YA1362)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat

Related Diseases

Diseases	Alias
Nevus Comedonicus	Nevus Comedonicus Syndrome NC Nevus Comedonicus, Somatic
Arthrogryposis, Perthes Disease, And Upward Gaze Palsy	APUG
Lethal Congenital Contracture Syndrome 10	Nek9-Related Lethal Skeletal Dysplasia LCCS10 Lethal Skeletal Dysplasia-Fetal Akinesia-Contractures-Thoracic Dysplasia-Pulmonary Hypoplasia Syndrome
Goldberg-Shprintzen Syndrome	Goldberg-Shprintzen Megacolon Syndrome GOSHS Megacolon-Microcephaly Syndrome
Avascular Necrosis	Avn
Nephronophthisis 9	NPHP9 Nephronophthisis, Type 9
Lethal Congenital Contracture Syndrome	Lccs Lethal Congenital Contracture Syndrome 1
Combined Oxidative Phosphorylation Deficiency 16	COXPD16 Infantile Hypertrophic Cardiomyopathy Due To Mrpl44 Deficiency Combined Oxidative Phosphorylation Defect Type 16 Combined Oxidative Phosphorylation Deficiency, Type 16
Nephronophthisis 16	NPHP16 Nephronophthisis, Type 16
Nephronophthisis 20	NPHP20
Nephronophthisis 7	NPHP7 Nephronophthisis, Type 7
Nephronophthisis 14	Joubert Syndrome 19 NPHP14 JBTS19 Nephronophthisis, Type 14
Uterine Adnexa Cancer
Lethal Congenital Contracture Syndrome 2	LCCS2 Lethal Congenital Contractural Syndrome 2 Multiple Contracture Syndrome, Israeli-Bedouin Type Multiple Contracture Syndrome, Israeli Bedouin Type A Multiple Contracture Syndrome, Israeli Bedouin Type Lethal Congenital Contracture Syndrome Type 2 Israeli Bedouin Multiple Contracture Syndrome Type A Contracture Syndrome, Lethal, Congenital, Type 2
Nephronophthisis 2	NPHP2 Nph2 Nephronophthisis 2, Infantile Infantile Nephronophthisis 2 Infantile Nephronophthisis Nephronophthisis, Type 2
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Renal-Hepatic-Pancreatic Dysplasia	Ivemark'S Syndrome Ivemark Ii Syndrome Renohepaticopancreatic Dysplasia
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Senior-Loken Syndrome 1	Senior-Loken Syndrome Renal Dysplasia And Retinal Aplasia Renal-Retinal Syndrome Loken-Senior Syndrome Juvenile Nephronophthisis With Leber Amaurosis SLSN1 Senior-Loken Syndrome-1 Loken Senior Syndrome Senior Loken Syndrome Renal Dysplasia Retinal Aplasia Nephronophthisis With Retinal Dystrophy Renal Dysplasia-Retinal Aplasia Syndrome Slsn
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122639	ZINC05007751		99.33%	Unkown
HY-148062	RSS0680	Degrader	99.85%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-RS09200	NEK9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21389	Nek9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27908	Nek9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NEK9	VGNC	VGNC:31999
Mus musculus	NEK9	MGD	MGI:2387995
Canis familiaris	NEK9	VGNC	VGNC:43735
Macaca mulatta	NEK9	VGNC	VGNC:75209
Felis catus	NEK9	VGNC	VGNC:63770
Rattus norvegicus	NEK9	RGD	RGD:1307187
Others	NEK9	NCBI