KBTBD6 - kelch repeat and BTB domain containing 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89890

Summary

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

KBTBD6 Products (1)

mRNA Protein Name
NM_152903.5 NP_690867.3 kelch repeat and BTB domain-containing protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
25684205 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
25684205 GOA
involved in regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
25684205 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
25684205 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
25684205 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25684205 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KBTBD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KBTBD6 Q86V97 MAP1LC3C Homo sapiens Q9BXW4
ITC
25684205
Intra
KBTBD6 Q86V97 MAP1LC3C Homo sapiens Q9BXW4
Pull Down
20562859
Intra
KBTBD6 Q86V97 MAP1LC3B Homo sapiens Q9GZQ8
Anti Tag CoIP
25684205
Intra
KBTBD6 Q86V97 MAP1LC3B Homo sapiens Q9GZQ8
NMR
25684205
Intra
KBTBD6 Q86V97 MAP1LC3B Homo sapiens Q9GZQ8
ITC
25684205
Intra
KBTBD6 Q86V97 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra
KBTBD6 Q86V97 GABARAP Homo sapiens O95166
Anti Tag CoIP
25684205
Intra
KBTBD6 Q86V97 GABARAP Homo sapiens O95166
ITC
25684205
Intra
KBTBD6 Q86V97 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
KBTBD6 Q86V97 GABARAP Homo sapiens O95166
X-Ray Diffraction
25684205
Intra
KBTBD6 Q86V97 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra
KBTBD6 Q86V97 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
25684205
Intra
KBTBD6 Q86V97 GABARAPL2 Homo sapiens P60520
ITC
25684205
Intra
KBTBD6 Q86V97 GABARAPL1 Homo sapiens Q9H0R8
ITC
25684205
Intra
KBTBD6 Q86V97 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Intra
KBTBD6 Q86V97 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
25684205
Intra
KBTBD6 Q86V97 GABARAPL1 Homo sapiens Q9H0R8
Confocal
25684205
Intra
KBTBD6 Q86V97 GABARAPL1 Homo sapiens Q9H0R8
NMR
25684205
Cross: Cross-species interaction Intra: Intraspecies interaction