ZNF24 - zinc finger protein 24 Gene

Also Known as KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7572

About ZNF24

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:35,332,227-35,344,420 (from NCBI)

This gene has 6 transcripts (splice variants), 105 orthologues and 31 paralogues. Ubiquitous expression in thyroid (RPKM 22.0), brain (RPKM 18.9) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF24 Products (3)

mRNA Protein Name
NM_001308123.2 NP_001295052.1 zinc finger protein 24 isoform 2
NM_001375815.1 NP_001362744.1 zinc finger protein 24 isoform 1
NM_006965.4 NP_008896.2 zinc finger protein 24 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11532988 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
31515488 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11532988 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10585455 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11532988 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF24 Protein Structure

SCAN

SCAN: SCAN domain (47 - 140)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (268 - 290)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (294 - 317)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (322 - 345)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
Protein Preferred Names Protein Names

zinc finger protein 24

  • retinoic acid suppression protein A

ZNF24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF24 P17028 ZSCAN22 Homo sapiens P10073
Y2H Array
32296183
Intra
ZNF24 P17028 ZSCAN22 Homo sapiens P10073
Y2H Prey Pooling
32296183
Intra
ZNF24 P17028 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
ZNF24 P17028 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
ZNF24 P17028 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
ZNF24 P17028 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
ZNF24 P17028 ZNF483 Homo sapiens Q6P088
Y2H Array
25416956
Intra
ZNF24 P17028 ZSCAN21 Homo sapiens Q9Y5A6
Validated Y2H
32296183
Intra
ZNF24 P17028 PGBD1 Homo sapiens Q96JS3
Y2H Array
31515488
Intra
ZNF24 P17028 PGBD1 Homo sapiens Q96JS3
Y2H Array
25416956
Intra
ZNF24 P17028 ZNF174 Homo sapiens Q15697-2
Validated Y2H
32296183
Intra
ZNF24 P17028 ZNF174 Homo sapiens Q15697-2
Anti Tag CoIP
28514442
Intra
ZNF24 P17028 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
ZNF24 P17028 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
ZNF24 P17028 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra
ZNF24 P17028 ZNF444 Homo sapiens Q8N0Y2-2
Validated Y2H
32296183
Intra
ZNF24 P17028 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra
ZNF24 P17028 APOE Homo sapiens P02649
Y2H Array
32814053
Intra
ZNF24 P17028 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra
ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
Validated Y2H
32296183
Intra
ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
Y2H Array
32296183
Intra
ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
Y2H Prey Pooling
32296183
Intra
ZNF24 P17028 ZNF396 Homo sapiens Q96N95-3
MAPPIT
32296183
Intra
ZNF24 P17028 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra
ZNF24 P17028 ZKSCAN4 Homo sapiens Q969J2
Y2H Array
31515488
Intra
ZNF24 P17028 ZKSCAN4 Homo sapiens Q969J2
Validated Y2H
32296183
Intra
ZNF24 P17028 SQSTM1 Homo sapiens Q13501
Validated Y2H
32814053
Intra
ZNF24 P17028 SQSTM1 Homo sapiens Q13501
Y2H Array
32814053
Intra
ZNF24 P17028 SQSTM1 Homo sapiens Q13501
Y2H Pooling
32814053
Intra
ZNF24 P17028 DDX6 Homo sapiens P26196
Validated Y2H
25416956
Intra
ZNF24 P17028 DDX6 Homo sapiens P26196
Y2H Prey Pooling
25416956
Intra
ZNF24 P17028 DDX6 Homo sapiens P26196
Y2H Array
25416956
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9
Anti Tag CoIP
28514442
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9
Anti Tag CoIP
33961781
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9
Y2H Array
20211142
Intra
ZNF24 P17028 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra
ZNF24 P17028 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
ZNF24 P17028 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
ZNF24 P17028 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
ZNF24 P17028 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ZNF24 P17028 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ZNF24 P17028 ZSCAN23 Homo sapiens Q3MJ62
Validated Y2H
32296183
Intra
ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Y2H Prey Pooling
25416956
Intra
ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Validated Y2H
25416956
Intra
ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Y2H Array
25416956
Intra
ZNF24 P17028 ZSCAN32 Homo sapiens Q9NX65
Y2H Pooling
16189514
Intra
ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Pooling
16189514
Intra
ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Array
31515488
Intra
ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Prey Pooling
32296183
Intra
ZNF24 P17028 YJU2B Homo sapiens P13994
Y2H Array
32296183
Intra
ZNF24 P17028 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra
ZNF24 P17028 ZSCAN16 Homo sapiens Q9H4T2
Validated Y2H
32296183
Intra
ZNF24 P17028 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
ZNF24 P17028 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Y2H Prey Pooling
25416956
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Complementation
32296183
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Y2H Pooling
16189514
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra
ZNF24 P17028 ZNF446 Homo sapiens Q9NWS9-2
MAPPIT
32296183
Intra
ZNF24 P17028 ZNF165 Homo sapiens P49910
Y2H Array
32296183
Intra
ZNF24 P17028 ZNF165 Homo sapiens P49910
Y2H Prey Pooling
32296183
Intra
ZNF24 P17028 ZNF165 Homo sapiens P49910
Validated Y2H
32296183
Intra
ZNF24 P17028 SCAND1 Homo sapiens P57086
Validated Y2H
32296183
Intra
ZNF24 P17028 SCAND1 Homo sapiens P57086
Y2H Pooling
16189514
Intra
ZNF24 P17028 SCAND1 Homo sapiens P57086
Anti Tag CoIP
28514442
Intra
ZNF24 P17028 SCAND1 Homo sapiens P57086
Anti Tag CoIP
33961781
Intra
ZNF24 P17028 APLP1 Homo sapiens P51693
Y2H Pooling
16169070
Intra
ZNF24 P17028 ZNF232 Homo sapiens Q9UNY5
Validated Y2H
32296183
Intra
ZNF24 P17028 TCAF1 Homo sapiens Q9Y4C2
Y2H Prey Pooling
25416956
Intra
ZNF24 P17028 TCAF1 Homo sapiens Q9Y4C2
Y2H Array
25416956
Intra
ZNF24 P17028 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Intra
ZNF24 P17028 DZIP3 Homo sapiens Q86Y13
Y2H Array
29892012
Intra
ZNF24 P17028 DZIP3 Homo sapiens Q86Y13
Y2H Prey Pooling
25416956
Intra
ZNF24 P17028 DZIP3 Homo sapiens Q86Y13
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16114 ZNF24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZNF24 VGNC VGNC:107735
Mus musculus ZNF24 MGD MGI:1929704
Macaca mulatta ZNF24 VGNC VGNC:81614
Rattus norvegicus ZNF24 RGD RGD:727963
Bos taurus ZNF24 VGNC VGNC:37232
Canis familiaris ZNF24 VGNC VGNC:48680
Others ZNF24 NCBI