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ZSCAN21 - zinc finger and SCAN domain containing 21 Gene

Also Known as ZNF38; Zipro1; NY-REN-21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7589

About ZSCAN21

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,049,774-100,065,040 (from NCBI)

This gene has 4 transcripts (splice variants), 88 orthologues and 31 paralogues. Ubiquitous expression in testis (RPKM 4.9), endometrium (RPKM 3.1) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZSCAN21 Products (4)

mRNA	Protein	Name
NM_001362779.2	NP_001349708.1	zinc finger and SCAN domain-containing protein 21 isoform 1
NM_001362780.2	NP_001349709.1	zinc finger and SCAN domain-containing protein 21 isoform 1
NM_001362781.2	NP_001349710.1	zinc finger and SCAN domain-containing protein 21 isoform 2
NM_145914.3	NP_666019.1	zinc finger and SCAN domain-containing protein 21 isoform 1

ZSCAN21 Protein Structure

SCAN

zf-H2C2_2

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
zinc finger and SCAN domain-containing protein 21	renal carcinoma antigen NY-REN-21

ZSCAN21 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZSCAN21	Q9Y5A6	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	ZSCAN21	Q9Y5A6	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	ZSCAN21	Q9Y5A6	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	ZSCAN21	Q9Y5A6	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	ZSCAN21	Q9Y5A6	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	25416956
Intra	ZSCAN21	Q9Y5A6	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZSCAN22	Homo sapiens	P10073	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZSCAN22	Homo sapiens	P10073	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF483	Homo sapiens	Q6P088	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF483	Homo sapiens	Q6P088	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZKSCAN7	Homo sapiens	Q9P0L1-2	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZKSCAN7	Homo sapiens	Q9P0L1-2	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZSCAN12	Homo sapiens	O43309	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZSCAN12	Homo sapiens	O43309	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF396	Homo sapiens	Q96N95-3	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF396	Homo sapiens	Q96N95-3	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF213	Homo sapiens	O14771	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF213	Homo sapiens	O14771	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF24	Homo sapiens	P17028	Anti Tag CoIP	33961781
Intra	ZSCAN21	Q9Y5A6	ZNF24	Homo sapiens	P17028	Y2H Prey Pooling	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF24	Homo sapiens	P17028	Validated Y2H	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF24	Homo sapiens	P17028	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF24	Homo sapiens	P17028	Y2H Array	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF24	Homo sapiens	P17028	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	25416956
Intra	ZSCAN21	Q9Y5A6	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	25416956
Intra	ZSCAN21	Q9Y5A6	TRIM41	Homo sapiens	Q8WV44	Y2H Array	25416956
Intra	ZSCAN21	Q9Y5A6	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Array	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF446	Homo sapiens	Q9NWS9-2	Validated Y2H	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF446	Homo sapiens	Q9NWS9-2	Y2H Prey Pooling	25416956
Intra	ZSCAN21	Q9Y5A6	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	GRAP2	Homo sapiens	O75791	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	ZKSCAN7	Homo sapiens	Q9P0L1	Y2H Array	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF496	Homo sapiens	Q96IT1	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	ZNF496	Homo sapiens	Q96IT1	Validated Y2H	25416956
Intra	ZSCAN21	Q9Y5A6	ZNF496	Homo sapiens	Q96IT1	Y2H Array	32296183
Intra	ZSCAN21	Q9Y5A6	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	ZSCAN21	Q9Y5A6	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16200	ZSCAN21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZSCAN21	VGNC	VGNC:81892
Bos taurus	ZSCAN21	VGNC	VGNC:37377
Canis familiaris	ZSCAN21	VGNC	VGNC:54101
Rattus norvegicus	ZSCAN21	RGD	RGD:1309981
Mus musculus	ZSCAN21	MGD	MGI:99182
Others	ZSCAN21	NCBI