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  3. GRAP2 - GRB2 related adaptor protein 2 Gene

GRAP2 - GRB2 related adaptor protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2

Gene ID: 9402 | Gene type: protein coding

About GRAP2

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,893,820-39,973,721 (from NCBI)

This gene has 7 transcripts (splice variants), 260 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 6.7), spleen (RPKM 4.1) and 17 other tissues.

Summary

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

GRAP2 Products(5)

mRNA Protein Name
NM_001291824.2 NP_001278753.1 GRB2-related adapter protein 2 isoform 1
NM_001291825.1 NP_001278754.1 GRB2-related adapter protein 2 isoform 1
NM_001291826.2 NP_001278755.1 GRB2-related adapter protein 2 isoform 2
NM_001291828.2 NP_001278757.1 GRB2-related adapter protein 2 isoform 3
NM_004810.4 NP_004801.1 GRB2-related adapter protein 2 isoform 1

GRAP2 Protein Structure

SH3_1

SH3_1: SH3 domain (4 - 47)

SH2

SH2: SH2 domain (58 - 132)

SH3_1

SH3_1: SH3 domain (277 - 322)

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  • 330 a.a.
Protein Preferred Names Protein Names

GRB2-related adapter protein 2

GRB-2-like protein

Related Diseases

Diseases Alias
Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib

IGHD1B

Ighd Ib

Growth Hormone Deficiency, Isolated, Type Ib

Congenital Ighd Type Ib

Congenital Isolated Gh Deficiency Type Ib

Congenital Isolated Growth Hormone Deficiency Type Ib

Dwarfism Of Sindh

Pituitary Dwarfism I

Isolated Growth Hormone Deficiency Type 1b

Ighd 1b

Growth Hormone Deficiency, Isolated, 1b
Generalized Anxiety Disorder

Anxiety Generalized
Hypochondriasis

Hypochondriacal Disorder

Hypochondria

Hypochondriacal Neurosis

Illness Anxiety Disorder

Health Anxiety Disorder

Hypochondriacal Reaction
Somatization Disorder

Somatoform Disorders

Briquet'S Disorder

Polysomatising Disorder

Somatisation Disorder

Somatoform Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05776 GRAP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GRAP2 VGNC VGNC:73156
Canis familiaris GRAP2 VGNC VGNC:41470
Rattus norvegicus GRAP2 RGD RGD:1307605
Bos taurus GRAP2 VGNC VGNC:29627
Felis catus GRAP2 VGNC VGNC:67455
Mus musculus GRAP2 MGD MGI:1333842