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GAB2 - GRB2 associated binding protein 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9846

About GAB2

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:78,215,293-78,417,820 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 13.2), bone marrow (RPKM 11.6) and 25 other tissues.

Summary

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine Phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

GAB2 Products (2)

mRNA	Protein	Name
NM_012296.4	NP_036428.1	GRB2-associated-binding protein 2 isoform b
NM_080491.3	NP_536739.1	GRB2-associated-binding protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15170389	GOA
enables transmembrane receptor protein tyrosine kinase adaptor activity	IDA IDA: Inferred from direct assay	19172738	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	15750601	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19172738	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19172738	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19172738	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAB2 Protein Structure

0
200
400
600
676 a.a.

Protein Preferred Names	Protein Names
GRB2-associated-binding protein 2	Grb2-associated binder 2

GAB2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GAB2	Q9UQC2	ACP2	Homo sapiens	P11117	Y2H Pooling	32814053
Intra	GAB2	Q9UQC2	ACP2	Homo sapiens	P11117	Validated Y2H	32814053
Intra	GAB2	Q9UQC2	ACP2	Homo sapiens	P11117	Y2H Array	32814053
Intra	GAB2	Q9UQC2	EGFR	Homo sapiens	P00533	Anti Tag CoIP	19172738
Intra	GAB2	Q9UQC2	EGFR	Homo sapiens	P00533	Anti Tag CoIP	16253990
Intra	GAB2	Q9UQC2	PTPN11	Homo sapiens	Q06124	Anti Tag CoIP	16253990
Intra	GAB2	Q9UQC2	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	19172738
Intra	GAB2	Q9UQC2	YWHAB	Homo sapiens	P31946	Far-WB	19172738
Intra	GAB2	Q9UQC2	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	19172738
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Anti Bait CoIP	19172738
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Pull Down	10913131
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Anti Tag CoIP	31980649
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	GAB2	Q9UQC2	GRB2	Homo sapiens	P62993	Anti Tag CoIP	16253990
Intra	GAB2	Q9UQC2	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	GAB2	Q9UQC2	GRAP2	Homo sapiens	O75791	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Alzheimer'S Disease 1	Alzheimer Disease Type 1 Alzheimer'S Disease 1, Early Onset
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05198	GAB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22177	Gab2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28699	Gab2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GAB2	VGNC	VGNC:103013
Macaca mulatta	GAB2	VGNC	VGNC:72721
Rattus norvegicus	GAB2	RGD	RGD:621367
Mus musculus	GAB2	MGD	MGI:1333854
Others	GAB2	NCBI