GAREM1 - GRB2 associated regulator of MAPK1 subtype 1 Gene

Also Known as GAREM; Gm944; FAM59A; C18orf11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64762

Summary

This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Ubiquitous expression in kidney (RPKM 5.8), brain (RPKM 4.3) and 23 other tissues.

GAREM1 Products (1)

mRNA Protein Name
NG_030329.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables proline-rich region binding IDA
IDA: Inferred from direct assay
19509291 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19509291 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to epidermal growth factor stimulus IDA
IDA: Inferred from direct assay
19509291 GOA
involved in epidermal growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19509291 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19509291 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19509291 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAREM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GAREM1 Q9H706 GRB2 Homo sapiens P62993
Y2H Array
32296183
Intra
GAREM1 Q9H706 GRB2 Homo sapiens P62993
Anti Tag CoIP
33961781
Intra
GAREM1 Q9H706 GRB2 Homo sapiens P62993
Validated Y2H
25416956
Intra
GAREM1 Q9H706 GRB2 Homo sapiens P62993
Y2H
21988832
Intra
GAREM1 Q9H706 GRB2 Homo sapiens P62993
Y2H Prey Pooling
25416956
Intra
GAREM1 Q9H706 GRB2 Homo sapiens P62993
Y2H Prey Pooling
32296183
Intra
GAREM1 Q9H706 GRAP2 Homo sapiens O75791
Y2H Prey Pooling
32296183
Intra
GAREM1 Q9H706 GRAP2 Homo sapiens O75791
Y2H Array
25814554
Intra
GAREM1 Q9H706 GRAP2 Homo sapiens O75791
Y2H Array
32296183
Intra
GAREM1 Q9H706 CRK Homo sapiens P46108
Y2H Array
25814554
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05784 GREM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17341 Grem1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23796 Grem1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown