ATG16L1 - autophagy related 16 like 1 Gene

Also Known as IBD10; WDR30; APG16L; ATG16A; ATG16L

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55054

About ATG16L1

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,251,673-233,295,669 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 207 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 12.7), testis (RPKM 12.0) and 25 other tissues.

Summary

The protein encoded by this gene is part of a large protein complex that is necessary for Autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

ATG16L1 Products (6)

mRNA	Protein	Name
NM_001190266.2	NP_001177195.1	autophagy-related protein 1月16日 isoform 4
NM_001190267.2	NP_001177196.1	autophagy-related protein 1月16日 isoform 5
NM_001363742.2	NP_001350671.1	autophagy-related protein 1月16日 isoform 6
NM_017974.4	NP_060444.3	autophagy-related protein 1月16日 isoform 2
NM_030803.7	NP_110430.5	autophagy-related protein 1月16日 isoform 1
NM_198890.3	NP_942593.2	autophagy-related protein 1月16日 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables protein-membrane adaptor activity	IMP IMP: Inferred from mutant phenotype	30778222	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in C-terminal protein lipidation	IDA IDA: Inferred from direct assay	33586810	GOA
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	30778222	GOA
involved in macroautophagy	IDA IDA: Inferred from direct assay	29317426	GOA
involved in microautophagy	IDA IDA: Inferred from direct assay	29317426	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Atg12-Atg5-Atg16 complex	IDA IDA: Inferred from direct assay	29317426	GOA
part of Atg12-Atg5-Atg16 complex	IPI IPI: Inferred from physical interaction	23202584	GOA
is active in autophagosome membrane	IDA IDA: Inferred from direct assay	29317426	GOA
is active in endolysosome membrane	IDA IDA: Inferred from direct assay	29317426	GOA
located in vacuole-isolation membrane contact site	IDA IDA: Inferred from direct assay	28890335	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG16L1 Protein Structure

ATG16

WD40

0
100
200
300
400
500
607 a.a.

Protein Preferred Names	Protein Names
autophagy-related protein 16-1	APG16L beta

ATG16L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATG16L1	Q676U5	ATG5	Homo sapiens	Q9H1Y0	Anti Tag CoIP	23392225
Intra	ATG16L1	Q676U5	ATG5	Homo sapiens	Q9H1Y0	Anti Tag CoIP	20562859
Intra	ATG16L1	Q676U5	ATG5	Homo sapiens	Q9H1Y0	Anti Tag CoIP	33961781
Intra	ATG16L1	Q676U5	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	23392225
Intra	ATG16L1	Q676U5	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	ATG16L1	Q676U5	RAB33B	Homo sapiens	Q9H082	Validated Y2H	32296183
Intra	ATG16L1	Q676U5	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ATG16L1	Q676U5	ATG12	Homo sapiens	O94817	Anti Tag CoIP	33961781
Intra	ATG16L1	Q676U5	TMEM59	Homo sapiens	Q9BXS4	Pull Down	23376921
Intra	ATG16L1	Q676U5	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

ATG16L1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82442	Atg16L1 Antibody (YA2187)	WB	Human, Mouse, Rat
HY-P82442A	Atg16L1 Antibody (YA2187)(PBS only)	WB	Human, Mouse, Rat
HY-P86193	Atg16L1 Antibody (YA5885)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease 10	Inflammatory Bowel Disease 10 IBD10 Inflammatory Bowel Disease 10, Susceptibility To Bowel Disease, Inflammatory, Type 10
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Colitis
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Inflammatory Bowel Disease 5	IBD5
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Inflammatory Bowel Disease 1	Inflammatory Bowel Disease 1 IBD1 Crohn Disease-Associated Growth Failure Crohn Disease Regional Enteritis Ulcerative Colitis Crohn Disease-Associated Growth Failure, Susceptibility To Inflammatory Bowel Disease 1, Crohn Disease Bowel Disease, Inflammatory, Type 1
Crohn'S Colitis	Crohn Disease
Inflammatory Bowel Disease 6	IBD6
Ileocolitis	Iieocolitis
Inflammatory Bowel Disease 9	IBD9
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Ileitis	Crohn'S Ileitis
Salmonellosis	Salmonella Infections Salmonella Infection
Autoimmune Disease Of Gastrointestinal Tract
Inflammatory Bowel Disease 18	IBD18
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100008	Peretinoin		99.79%	Unkown

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170998	ATG16L1 stabilizer-1	Inducer	/	Unkown
HY-183730	4E1RCat 17d	Inhibitor	/	Unkown
HY-183731	ATG5 PPI-IN-1		/	Unkown
HY-183737	ATG5/TECAIR-IN-1	Inhibitor	/	Unkown
HY-183738	4E1RCat 27d		/	Unkown
HY-183807	T1742	Inhibitor	/	Unkown
HY-183826	ATG5 PPI-IN-4	Inhibitor	/	Unkown
HY-183827	ATG5 PPI-IN-5	Inhibitor	/	Unkown
HY-183829	ATG5/TECAIR-IN-3	Inducer	/	Unkown
HY-183833	Autophagy-IN-9	Inhibitor	/	Unkown
HY-183835	Autophagy-IN-10	Inhibitor	/	Unkown
HY-183838	Autophagy-IN-11	Inhibitor	/	Unkown
HY-183848	ATG5/TECAIR-IN-4	Inhibitor	/	Unkown
HY-183867	ATG5 PPI-IN-6	Inhibitor	/	Unkown
HY-RS01143	ATG16L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183732	ATG5 PPI-IN-2	Inhibitor	/	Unkown
HY-183736	Autophagy-IN-12	Inhibitor	/	Unkown
HY-183828	ATG5/TECAIR-IN-2	Inhibitor	/	Unkown
HY-RS19832	Atg16l1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26329	Atg16l1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ATG16L1	VGNC	VGNC:70108
Felis catus	ATG16L1	VGNC	VGNC:59998
Bos taurus	ATG16L1	VGNC	VGNC:26253
Mus musculus	ATG16L1	MGD	MGI:1924290
Rattus norvegicus	ATG16L1	RGD	RGD:1310631
Canis familiaris	ATG16L1	VGNC	VGNC:38219
Others	ATG16L1	NCBI