2. Gene
  3. ATG16L1 - autophagy related 16 like 1 Gene

ATG16L1 - autophagy related 16 like 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IBD10; WDR30; APG16L; ATG16A; ATG16L

Gene ID: 55054 | Gene type: protein coding

About ATG16L1

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,251,673-233,295,669 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 207 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 12.7), testis (RPKM 12.0) and 25 other tissues.

Summary

The protein encoded by this gene is part of a large protein complex that is necessary for Autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]

ATG16L1 Products(6)

mRNA Protein Name
NM_001190266.2 NP_001177195.1 autophagy-related protein 1月16日 isoform 4
NM_001190267.2 NP_001177196.1 autophagy-related protein 1月16日 isoform 5
NM_001363742.2 NP_001350671.1 autophagy-related protein 1月16日 isoform 6
NM_017974.4 NP_060444.3 autophagy-related protein 1月16日 isoform 2
NM_030803.7 NP_110430.5 autophagy-related protein 1月16日 isoform 1
NM_198890.3 NP_942593.2 autophagy-related protein 1月16日 isoform 3

ATG16L1 Protein Structure

ATG16

ATG16: Autophagy protein 16 (ATG16) (13 - 207)

WD40

WD40: WD domain, G-beta repeat (315 - 350)

WD40

WD40: WD domain, G-beta repeat (357 - 393)

WD40

WD40: WD domain, G-beta repeat (402 - 436)

WD40

WD40: WD domain, G-beta repeat (539 - 562)

WD40

WD40: WD domain, G-beta repeat (574 - 604)

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  • 607 a.a.
Protein Preferred Names Protein Names

autophagy-related protein 16-1

APG16L beta

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 10

Inflammatory Bowel Disease 10

IBD10

Inflammatory Bowel Disease 10, Susceptibility To

Bowel Disease, Inflammatory, Type 10
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Colitis
Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis
Inflammatory Bowel Disease 5

IBD5
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1
Crohn'S Colitis

Crohn Disease
Inflammatory Bowel Disease 6

IBD6
Ileocolitis

Iieocolitis
Inflammatory Bowel Disease 9

IBD9
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Ileitis

Crohn'S Ileitis
Salmonellosis

Salmonella Infections

Salmonella Infection
Autoimmune Disease Of Gastrointestinal Tract
Inflammatory Bowel Disease 18

IBD18
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100008 Peretinoin 99.79% Yes
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01143 ATG16L1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ATG16L1 VGNC VGNC:70108
Felis catus ATG16L1 VGNC VGNC:59998
Bos taurus ATG16L1 VGNC VGNC:26253
Mus musculus ATG16L1 MGD MGI:1924290
Rattus norvegicus ATG16L1 RGD RGD:1310631
Canis familiaris ATG16L1 VGNC VGNC:38219