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Art. -Nr.: HY-183736

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Autophagy-IN-12

Autophagy-IN-12 is a Autophagy inhibitor. Autophagy-IN-12 exhibits an IC₅₀ value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR.

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CAS. Nr.: 2841473-93-4
Formel: C₃₀H₂₂N₂O₅
Molecular Weight:490.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Autophagy-IN-12 Chemical Structure

CAS. Nr.: 2841473-93-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Autophagy-IN-12 is a Autophagy inhibitor. Autophagy-IN-12 exhibits an IC₅₀ value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR^[1].

In Vitro

Autophagy-IN-12 (Compound 17e) exhibits an IC₅₀ value of >33 μM for both ATG5-ATG16L1 and ATG5-TECAIR protein-protein interactions^[1].
Autophagy-IN-12 (20 μM; 6 h) increases the autophagy rate of COS-7 cells to 38.94%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

COS-7
Concentration:

20 μM
Incubation Time:

6 h
Result:

Resulted in an autophagy incidence of 38.94% in COS-7 cells.

Related Protocols :

Chemical Information

CAS. Nr. 2841473-93-4
Molecular Weight 490.51
Formel C₃₀H₂₂N₂O₅
SMILES

NC(C(C=C1)=CC=C1C2=CC=C(O2)/C=C(C3=O)\C=C(C4=CC=CC=C4)N3CC5=CC=C(C=C5)C(O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 23;66(4):2457-2476. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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