country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-183835

Copy Link Print Information

Autophagy-IN-10

Autophagy-IN-10 is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC₅₀ value of 2.29 μM against ATG5-ATG16L1 and an IC₅₀ value of 3.68 μM against ATG5-TECAIR.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2841473-75-2
Formel: C₂₉H₂₀N₂O₆
Molecular Weight:492.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Autophagy-IN-10 Chemical Structure

CAS. Nr.: 2841473-75-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Autophagy-IN-10 (Compound 12a) inhibits the ATG5-ATG16L1 and ATG5-TECAIR protein-protein interactions with IC₅₀ values of 2.29 μM and 3.68 μM, respectively^[1].
Autophagy-IN-10 (20 μM; 6 h) reduces autophagy incidence in COS-7 cells to 5.88%, effectively inhibiting autophagy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

COS-7 cells
Concentration:

20 μM
Incubation Time:

6 h
Result:

Reduced autophagy incidence in COS-7 cells to 5.88%.

Chemical Information

CAS. Nr. 2841473-75-2
Molecular Weight 492.48
Formel C₂₉H₂₀N₂O₆
SMILES

O=C(N(C(C1=CC=CC=C1)=C/2)CC3=CC=C(C=C3)C(O)=O)C2=C\C4=CC=C(C5=CC=C(C=C5)[N+]([O-])=O)O4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 23;66(4):2457-2476. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen