Autophagy-IN-10
Autophagy-IN-10 is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC50 value of 2.29 μM against ATG5-ATG16L1 and an IC50 value of 3.68 μM against ATG5-TECAIR.
For research use only. We do not sell to patients.
- CAS No.: 2841473-75-2
- Formula: C29H20N2O6
- Molecular Weight:492.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Autophagy-IN-10 (Compound 12a) inhibits the ATG5-ATG16L1 and ATG5-TECAIR protein-protein interactions with IC50 values of 2.29 μM and 3.68 μM, respectively[1].
Autophagy-IN-10 (20 μM; 6 h) reduces autophagy incidence in COS-7 cells to 5.88%, effectively inhibiting autophagy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:COS-7 cells
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Concentration:20 μM
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Incubation Time:6 h
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Result:Reduced autophagy incidence in COS-7 cells to 5.88%.
Chemical Information
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CAS No. 2841473-75-2
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Molecular Weight 492.48
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Formula C29H20N2O6
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SMILES
O=C(N(C(C1=CC=CC=C1)=C/2)CC3=CC=C(C=C3)C(O)=O)C2=C\C4=CC=C(C5=CC=C(C=C5)[N+]([O-])=O)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autophagy-IN-10 Related Classifications
HY-183835 Related Classifications
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